Figure 4

Semiquantitative analysis of villous explant outgrowth and migration. Explants from four placentas (at the gestational ages of 9, 12, 16, and 20 wk) were cultured in the presence or absence of SERPINE2 siRNA for 120 h, and the migration score based on a scale (see Methods and Additional file 3, Figure S2) was evaluated by 2 observers. Data are presented as the mean ± SEM. * p < 0.05 ** p < 0.01.