Figure 5

Increased proliferation and surface area in endometrial blood vessels in response to VEGF-D over-expression. Uterine horns of NOD SCID mice were inoculated with control or VEGF-D expressing 293EBNA cells. The density of endometrial blood vessels (A) did not vary between mice treated with VEGF-expressing cells relative to control cells. However, the percentage of endometrial blood vessels that contained proliferating cells (B) at sites adjacent to tumors was significantly increased in mice treated with VEGF-D cells, relative to control cells. Similarly, the surface area of endometrial blood vessels (C) was significantly increased in sites adjacent to VEGF-D expressing tumors relative to control tumours. Black bars: control cells; White bars: VEGF-D cells. Data are illustrated as means ± SEM (n = 7-9). Groups that do not share a letter in common are significantly different (P < 0.05).