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Table 1 Subject characteristics, pregnancy outcome, and serum levels of MMPs and TIMPs, pregnant women with a history of RPL vs. pregnant women with no history of RPL

From: Circulating levels of matrix proteases and their inhibitors in pregnant women with and without a history of recurrent pregnancy loss

  History of recurrent pregnancy loss, RPL No history of recurrent pregnancy loss, NRPL P value
n 20 20  
Median (range) age (yrs) 32.5 (20 - 43) 31.0 (24-41) 0.8
Mean (SE) birth weight (g) 3040 (206) 3364 (216) 0.15
Infant birth weight < 2500 g, n (%) 7 (35) 3 (15) 0.15
Small for gestational age (birth weight < 10th centile) 5 (25%) 0 0.048
Mean (SE) serum MMP-1 levels in ng/ml    
6-8 wks 346 (36) 438 (104) 0.35
10-12 wks 355 (52) 366 (55) 0.69
20 wks 337 (29) 380 (71) 0.55
34 wks 524 (52) 529 (104) 0.97
Cord serum 375 (41) 476 (115) 0.36
Mean (SE) serum MMP-3 levels in ng/ml    
6-8 wks 5.6 (0.7) 3.2 (0.4) 0.01
10-12 wks 7.4 (2.4) 5.2 (0.7) 0.39
20 wks 5.3 (0.7) 5 (0.7) 0.74
34 wks 4.7 (0.6) 5 (0.6) 0.64
Cord serum 1.8 (0.4) 1.8 (0.4) 0.90
Mean (SE) serum MMP-9 levels in ng/ml    
6-8 wks 70.0 (6.9) 86.0 (15.3) 0.31
10-12 wks 91.5 (10.3) 83.3 (13.0 0.62
20 wks 105.8 (12.4) 80.6 (12.8) 0.15
34 wks 89.4 (11.3) 111.8 (14.6) 0.23
Cord serum 47.6 (8.7) 51.7 (7.4) 0.72
Mean (SE) serum TIMP-1 levels in ng/ml)    
6-8 wks 20.0 (2.0) 17. 1 (2.4) 0.37
10-12 wks 23.7 (1.8) 20.6 (3.5) 0.42
20 wks 23.9 (2.8) 23.3 (2.7) 0.88
34 wks 18.4 (2.1) 18.9 (2.4) 0.87
Cord serum 17.9 (2.7) 21.7 (3.0) 0.35
Mean (SE) serum TIMP-2 levels in ng/ml    
6-8 wks 36.0 (8.4) 13.8 (1.4) 0.01
10-12 wks 31.0(5.2) 11.7 (1.1) 0.002
20 wks 23.6 (5.2) 9.9 (0.9) 0.008
34 wks 23.7 (3.2) 16.9 (1.3) 0.05
Cord serum 16.7 (6.1 11.1 (1.1) 0.44
Relaxin:TIMP-2 ratio*    
6-8 wks 0.05 (0.01) 0.18 (0.03) 0.006
10-12 wks 0.05 (0.01) 0.17 (0.03) 0.0001
20 wks 0.03 (0.01) 0.08 (0.02) 0.03
34 wks 0.04 (0.01) 0.13 (0.02) 0.02
Cord serum 0.01 (0.01) 0.00 (0.00) 0.13
  1. * Relaxin levels were derived from an earlier assay [9].