Table 1 Subject characteristics, pregnancy outcome, and serum levels of MMPs and TIMPs, pregnant women with a history of RPL vs. pregnant women with no history of RPL
| Â | History of recurrent pregnancy loss, RPL | No history of recurrent pregnancy loss, NRPL | P value |
|---|---|---|---|
n | 20 | 20 | Â |
Median (range) age (yrs) | 32.5 (20 - 43) | 31.0 (24-41) | 0.8 |
Mean (SE) birth weight (g) | 3040 (206) | 3364 (216) | 0.15 |
Infant birth weight < 2500 g, n (%) | 7 (35) | 3 (15) | 0.15 |
Small for gestational age (birth weight < 10th centile) | 5 (25%) | 0 | 0.048 |
Mean (SE) serum MMP-1 levels in ng/ml | Â | Â | Â |
6-8 wks | 346 (36) | 438 (104) | 0.35 |
10-12 wks | 355 (52) | 366 (55) | 0.69 |
20 wks | 337 (29) | 380 (71) | 0.55 |
34 wks | 524 (52) | 529 (104) | 0.97 |
Cord serum | 375 (41) | 476 (115) | 0.36 |
Mean (SE) serum MMP-3 levels in ng/ml | Â | Â | Â |
6-8 wks | 5.6 (0.7) | 3.2 (0.4) | 0.01 |
10-12 wks | 7.4 (2.4) | 5.2 (0.7) | 0.39 |
20 wks | 5.3 (0.7) | 5 (0.7) | 0.74 |
34 wks | 4.7 (0.6) | 5 (0.6) | 0.64 |
Cord serum | 1.8 (0.4) | 1.8 (0.4) | 0.90 |
Mean (SE) serum MMP-9 levels in ng/ml | Â | Â | Â |
6-8 wks | 70.0 (6.9) | 86.0 (15.3) | 0.31 |
10-12 wks | 91.5 (10.3) | 83.3 (13.0 | 0.62 |
20 wks | 105.8 (12.4) | 80.6 (12.8) | 0.15 |
34 wks | 89.4 (11.3) | 111.8 (14.6) | 0.23 |
Cord serum | 47.6 (8.7) | 51.7 (7.4) | 0.72 |
Mean (SE) serum TIMP-1 levels in ng/ml) | Â | Â | Â |
6-8 wks | 20.0 (2.0) | 17. 1 (2.4) | 0.37 |
10-12 wks | 23.7 (1.8) | 20.6 (3.5) | 0.42 |
20 wks | 23.9 (2.8) | 23.3 (2.7) | 0.88 |
34 wks | 18.4 (2.1) | 18.9 (2.4) | 0.87 |
Cord serum | 17.9 (2.7) | 21.7 (3.0) | 0.35 |
Mean (SE) serum TIMP-2 levels in ng/ml | Â | Â | Â |
6-8 wks | 36.0 (8.4) | 13.8 (1.4) | 0.01 |
10-12 wks | 31.0(5.2) | 11.7 (1.1) | 0.002 |
20 wks | 23.6 (5.2) | 9.9 (0.9) | 0.008 |
34 wks | 23.7 (3.2) | 16.9 (1.3) | 0.05 |
Cord serum | 16.7 (6.1 | 11.1 (1.1) | 0.44 |
Relaxin:TIMP-2 ratio* | Â | Â | Â |
6-8 wks | 0.05 (0.01) | 0.18 (0.03) | 0.006 |
10-12 wks | 0.05 (0.01) | 0.17 (0.03) | 0.0001 |
20 wks | 0.03 (0.01) | 0.08 (0.02) | 0.03 |
34 wks | 0.04 (0.01) | 0.13 (0.02) | 0.02 |
Cord serum | 0.01 (0.01) | 0.00 (0.00) | 0.13 |