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Table 1 Summary of estrous cycles recorded during 8 days, shortly after the conclusion of chemotherapy course.

From: Assessment of fertility protection and ovarian reserve with GnRH antagonist in rats undergoing chemotherapy with cyclophosphamide

 

Group I

(placebo)

Group II

(CPA)

Group III

(GnRHant + CPA)

Group IV

(GnRHant)

Chi-Square

(p value)

Number of surviving rats per group

9

10

12

9

-

Number of rats with a cyclic pattern (%)

9

(100)

9

(90)

11

(92)

9

(100)

2.50

(p = 0.48)

Number of rats with estrus/proestrus (%)

9

(100)

5

(50)

10

(83)

9

(100)

12.42

(p < 0.01)

  1. CPA, cyclophosphamide; GnRHant, gonadotropin-releasing hormone antagonist (cetrorelix).