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Table 6 Ability of the most commonly used automated professional laboratory immunometric hCG tests (all tests used by > 1% of USA market) to measure hCG variants [83, 84].

From: New discoveries on the biology and detection of human chorionic gonadotropin

Standard Abbott AxSym Baxter Stratus Siemens ACS180 Siemens Centaur Beckman Access Ortho Vitros Eci Tosoh A1A Roche Elecsys Siemens Immulite
Regular hCG + + + + + + + + +
Hyperglycosylated hCG + + + + + + + ? +
Nicked hCG + + + + + + + ? +
Nicked hyperglycosylated hCG + + + + + + + ? +
Nicked hCG missing βCTP - - - - - - X - +
Free β + ? ? ? ? + + + +
Hyperglycosylated free β + ? ? ? ? + + ? +
Urine, β-subunit core fragment - - - - - - - - +
  1. Most commercial tests were evaluated at multiple laboratories. Antigens appropriately recognized by assays (detection of standard varies from calibrated concentration by no more than 25%) are indicated by +. Those invariably detected in a specific assay (result more than 25% different from calibrated concentration) are indicated by ?, and those not detected at all are indicted by -.