New discoveries on the biology and detection of human chorionic gonadotropin

Table 6 Ability of the most commonly used automated professional laboratory immunometric hCG tests (all tests used by > 1% of USA market) to measure hCG variants [83, 84].

Standard	Abbott AxSym	Baxter Stratus	Siemens ACS180	Siemens Centaur	Beckman Access	Ortho Vitros Eci	Tosoh A1A	Roche Elecsys	Siemens Immulite
Regular hCG	+	+	+	+	+	+	+	+	+
Hyperglycosylated hCG	+	+	+	+	+	+	+	?	+
Nicked hCG	+	+	+	+	+	+	+	?	+
Nicked hyperglycosylated hCG	+	+	+	+	+	+	+	?	+
Nicked hCG missing βCTP	-	-	-	-	-	-	X	-	+
Free β	+	?	?	?	?	+	+	+	+
Hyperglycosylated free β	+	?	?	?	?	+	+	?	+
Urine, β-subunit core fragment	-	-	-	-	-	-	-	-	+

Most commercial tests were evaluated at multiple laboratories. Antigens appropriately recognized by assays (detection of standard varies from calibrated concentration by no more than 25%) are indicated by +. Those invariably detected in a specific assay (result more than 25% different from calibrated concentration) are indicated by ?, and those not detected at all are indicted by -.

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