Table 1 Summary of potential biochemical markers for the prediction (1. trimester, 2. trimester) or the detection (Manifest preeclampsia) of preeclampsia in maternal peripheral blood.
Plasma concentrations | |||||
|---|---|---|---|---|---|
Biochemical Marker | 1. trimester | 2. trimester | Manifest preeclampsia | Reported combinations for prediction | Altered levels are also correlated with |
sflt-1 | -- | ↑ | ↑ | - sEng, PlGF VEGF -Ultrasound | -- |
sEng | -- | ↑ | ↑ | -sflt-1, PlGF -Ultrasound | -IUGR -HELLP -SGA |
PlGF | ↓ | ↓ | ↓ | -sEng, sflt-1 | -SGA |
PP-13 | ↓ | ↑ | ↑ | -Ultrasound | -IUGR -Preterm delivery |
P-Selectin | ↑ | ↑ | ↑ | Activin A, sflt-1 Other adhesion molecules | -- |
Cell-free fetal DNA | ↑ | ↑ | ↑ | -Inhibin-A | -IUGR -polyhydramnios -trisomy 21 -preterm labour |
Cell free DNA | -- | -- | ↑ | ||
ADAM12 | ↓ | -- | -- | -- | -trisomy 21 -trisomy 18 -small for gestational age |
PTX3 | ↑ | ↑ | ↑ | -- | -IUGR |
PAPP-A | ↓ | ↓ | ↓ | -- | -birthweight |
Visfatin | -- | ↑↓ | ↑↓ | -- | -type-2 diabetes mellitus - gestational diabetes mellitus -obesity -IUGR |
Adreno- medullin | ↑ | ↑ | ↑ | -- | -vascular disorders |