Figure 1

Alignment of spiggin amino acid sequences. A. Conservation of the N-terminal region containing the signal peptide (boxed), the sequences utilized to synthesize the KTK and HRD peptides (bold with double line above sequence) and the glycosylation sequence (bold with single line above sequence). B. The central region of all spiggin proteins, except spiggin γ, contains one polymerization site (bold with single line above sequence). C. The C-terminal region of Spiggin 1.1 and 4, contain one additional polymerization site (bold with single line above sequence). Spaces (-) are inserted to allow the alignment of homologous amino acids.