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Table 3 Effects of 1,25(OH)2D3 on sperm metabolism

From: Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism

  Triglycerides
mg/106 sperms
Lipase activity (U/L)mmol/min/
mg protein
Acyl CoA dehydrogenase activity
nmol/min/mg protein
G6PDH
mmol/min/106 sperms
NC 0,08 ± 0.0013 0,5 ± 0.02 0,004 ± 0.0001 0,005 ± 0.0001
1,25(OH)2D3 0.01 nM 0,05 ± 0.001* 1,3 ± 0.04* 0,0039 ± 0.0001 0,0048 ± 0.0002
1,25(OH)2D3 0.1 nM 0,025 ± 0.0029** 1,8 ± 0.03** 0,0041 ± 0.0002 0,0047 ± 0.0002
1,25(OH)2D3 1 nM 0,015 ± 0.0032** 0,8 ± 0.032* 0,0040 ± 0.0003 0,0051 ± 0.00018
1,25(OH)2D3 10 nM 0,07 ± 0.002 0,6 ± 0.031 0,0038 ± 0.0001 0,0046 ± 0.0001
Ab VDR + 0.1 nM 1,25(OH)2D3 0,077 ± 0.0019 0,4 ± 0.041 0,0038 ± 0.0002 0,0049 ± 0.0002
CAP 0.06 ± 0.002 2,2 ± 0,045** 0,01 ± 0,0005** 0.01 ± 0,0003*
  1. Data are presented as mean ± S.D. of seven independent experiments performed in duplicate.
  2. *P < 0.05 versus control; ** P < 0.01 versus control (NC). CAP = capacitated sperms.