Figure 3
Batimastat effects on E 2 -induced changes in uterine stromal matrix density. Transmission electron microscopy analysis of endometrial stroma from animals pretreated with saline or batimastat (Bat: 40 mg/kg) 4 h prior to administration of E2 or saline injected 4 h prior to tissue collection. Panel A: Representative TEM micrographs of stromal matrix. Micrographs shown are typical from a total of 36 to 54 micrographs analyzed from 3-4 animals per treatment group; C = Collagen, S = Stromal cell, scale bar = 0.5 μm. Panel B: Quantified endometrial collagen density; one-way ANOVA, error bars represent ± SE for 3-4 animals per treatment group, total micrographs analyzed per time point range from 36 to 54; *P < 0.05 compared to saline control (Sal-Sal).