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Table 1 Morphometric analyses of testes in hpg mice after treatment with estradiol and/or rhFSH

From: Effects of estradiol and FSH on maturation of the testis in the hypogonadal (hpg) mouse

  cholesterol vehicle estradiol vehicle cholesterol 1 IU FSH estradiol 1 IU FSH cholesterol 5 IU FSH
N 3 4 4 5 5
body wt (g) 29.7 ± 3.2 30.0 ± 2.5 29.5 ± 2.5 29.8 ± 2.8 29.0 ± 3.2
testis wt (mg) 12.0 ± 0.1 24.2 ± 1.8a 27.2 ± 3.3a 27.2 ± 1.7a 46.6 ± 4.8abc
tubule diameter (μm) 50.3 ± 0.7 71.6 ± 3.3a 66.3 ± 1.6a 72.3 ± 2.2a 77.3 ± 3.5a
tubule volume (μl) 3.8 ± 0.7 11.2 ± 1.1a 12.1 ± 0.39 12.2 ± 1.1a 21.8 ± 2.3abc
tubule length (m) 2.2 ± 0.4 2.8 ± 0.2 3.3 ± 0.2 3.0 ± 0.2 4.6 ± 0.3abc
tubule (% testis) 76.9 ± 9.9 91.3 ± 1.4 92.5 ± 0.8a 87.9 ± 1.5 94.0 ± 0.7a
sem epith vol (μl) 3.6 ± 0.6 9.9 ± 0.9a 11.0 ± 0.2a 10.5 ± 0.9a 19.4 ± 2.0abc
lumen volume (μl) 0.1 ± 0.1 1.3 ± 0.3 1.6 ± 0.3 1.1 ± 0.1 2.4 ± 0.4
  1. Values are group mean ± SEM, n = number of mice where complete stereological analysis was carried out. aP < 0.05 vs cholesterol + vehicle, bP < 0.05 vs estradiol + vehicle, cP < 0.05 vs cholesterol + 1 IU FSH. sem epith vol = seminiferous epithelium volume