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Table 2 List of under-expressed in leiomyomas as compared to scar tissues (keloids/incesional scars)

From: Genomic and proteomic profiling II: Comparative assessment of gene expression profiles in leiomyomas, keloids, and surgically-induced scars

Gene Bank

Symbol

Fold Change

Probability

Function

AF004709

MAPK13

0.06

0.0002

apoptosis

AF010316

PTGES

0.09

0.0003

apoptosis

NM_014430

CIDEB

0.21

0.0014

apoptosis

AJ307882

TRADD

0.26

0.0007

apoptosis

BC041689

CASP1

0.31

0.0009

apoptosis

NM_014922

NALP1

0.31

0.0025

apoptosis

AF159615

FRAG1

0.33

0.0044

apoptosis

BC019307

BCL2L1

0.42

0.0027

apoptosis

NM_016426

GTSE1

0.43

0.0033

apoptosis

AK027080

LTBR

0.50

0.0047

apoptosis

M92287

CCND3

0.48

0.0028

cell cycle

AJ242501

MAP7

0.2

0.0001

structural molecule

AF381029

LMNA

0.3

0.00001

structural molecule

X83929

DSC3

0.009

0.0035

cell adhesion

AB025105

CDH1

0.01

0.0009

cell adhesion

AJ246000

SELL

0.21

0.002

cell adhesion

NM_003568

ANXA9

0.22

0.0031

cell adhesion

AF281287

PECAM1

0.36

0.0017

cell adhesion

J00124

KRT14

0.0001

0.0003

cytoskeleton/motility

BC034535

KRT6B

0.005

0.0043

cytoskeleton/motility

M19156

KRT10

0.018

0.001

cytoskeleton/motility

AJ551176

SDC1

0.039

0.0038

cytoskeleton/motility

NM_006478

GAS2L1

0.22

0.0016

cytoskeleton/motility

M34225

KRT8

0.26

0.0029

cytoskeleton/motility

NM_005886

KATNB1

0.27

0.0011

cytoskeleton/motility

AK024835

CNN2

0.47

0.003

cytoskeleton/motility

NM_006350

FST

0.11

0.00001

extracellular matrix

AF177941

COLSA3

0.14

0.00001

extracellular matrix

L22548

COL18A1

0.49

0.0011

extracellular matrix

M58051

FGFR3

0.007

0.0039

growth factor receptor

NM_004887

CXCL14

0.009

0.0014

chemokine

AF289090

BMP7

0.13

0.002

cytokine

K03222

TGFA

0.2

0.0048

growth factor

M31682

INHBB

0.20

0.00001

cytokine

NM_004750

CRLF1

0.26

0.0003

cytokine binding

NM_002514

NOV (CCN3)

0.28

0.0009

growth factor

NM_000685

AGTR1

0.30

0.005

growth factor receptor

D16431

HDGF

0.42

0.0046

creatine kinase

L36719

MAP2K3

0.22

0.0048

protein kinase activity

AJ290975

ITPKC

0.28

0.0036

protein kinase activity

NM_001569

IRAK1

0.33

0.0001

protein kinase activity

AB025285

ERBB2

0.45

0.0003

protein kinase

AF029082

SFN

0.001

0.0028

signal transduction

AB065865

HM74

0.04

0.0047

signal transduction

AA021034

LTB4R

0.06

0.0006

signal transduction

NM_004445

EPHB6

0.12

0.0038

signal transduction

AF025304

EPHB2

0.17

0.0021

signal transduction

AB026663

MC1R

0.17

0.0046

signal transduction

AF035442

VAV3

0.17

0.004

signal transduction

NM_014030

GIT1

0.21

0.0025

signal transduction

AB011152

CENTD1

0.21

0.0003

signal transduction

AK095244

CYB561

0.23

0.0001

signal transduction

AF106858

GPR56

0.23

0.0002

signal transduction

AF231024

CELSR1

0.23

0.0006

signal transduction

AF234887

CELSR2

0.24

0.0003

signal transduction

NM_007197

FZD10

0.25

0.0009

signal transduction

NM_014349

APOL3

0.25

0.002

signal transduction

NM_004039

ANXA2

0.27

0.0044

signal transduction

AI285986

THBD

0.29

0.0004

signal transduction

M57730

EFNA1

0.31

0.0032

signal transduction

NM_002118

HLA-DMB

0.33

0.0008

signal transduction

AF427491

TUBB4

0.36

0.001

signal transduction

NM_005279

GPR1

0.40

0.0033

signal transduction

X60592

TNFRSF5

0.40

0.0032

signal transduction

BC052968

EPHB3

0.42

0.0001

signal transduction

M64749

CMKOR1

0.46

0.0014

signal transduction

M21188

IDE

0.46

0.0031

signal transduction

AB018325

CENTD2

0.47

0.0004

signal transduction

AK054968

ITGB5

0.49

0.0005

signal transduction

NM_001730

KLF5

0.04

0.0021

transcription factor

NM_004350

RUNX3

0.08

0.0001

transcription factor

U34070

CEBPA

0.11

0.0005

transcription factor

AF062649

PTTG1

0.15

0.0039

transcription factor

NM_004235

KLF4

0.20

0.0005

transcription factor

X52773

RXRA

0.20

0.0011

transcription factor

AF202118

HOXD1

0.21

0.0006

transcription factor

NM_000376

VDR

0.21

0.0001

transcription factor

NM_006548

IMP-2

0.26

0.0031

transcription factor

NM_007315

STAT1

0.32

0.00001

transcription factor

NM_004430

EGR3

0.34

0.002

transcription factor

NM_003644

GAS7

0.36

0.0033

transcription factor

NM_005900

MADH1

0.48

0.0028

transcription factor

X14454

IRF1

0.49

0.0013

transcription factor

AF067572

STAT6

0.49

0.0001

transcription factor

NM_005596

NFIB

0.49

0.0041

transcription factor

AB002282

EDF1

0.40

0.0002

transcription coactivator

AK075393

CTSB

0.50

0.0016

protease activity

AB021227

MMP24

0.29

0.0001

protease activity

AB007774

CSTA

0.02

0.0018

cysteine protease inhibitor

AF143883

ALOX12

0.06

0.0016

catalytic activity

AF440204

PTGS1

0.08

0.00001

catalytic activity

NM_000777

CYP3A5

0.14

0.0041

catalytic activity

NM_016593

CYP39A1

0.21

0.0027

catalytic activity

BC001491

HMOX1

0.23

0.0028

catalytic activity

BC020734

PGDS

0.26

0.00001

catalytic activity

AL133324

GSS

0.39

0.002

catalytic activity

AF055027

CARM1

0.41

0.00001

catalytic activity

NM_001630

ANXA8

0.01

0.0006

calcium ion binding

AB011542

EGFL5

0.43

0.0001

calcium ion binding

NM_005979

S100A13

0.31

0.001

calcium ion binding

NM_020672

S100A14

0.02

0.0005

calcium ion binding

NM_005978

S100A2

0.003

0.005

calcium ion binding

BC012610

HF1

0.22

0.00001

complement activation

AF052692

GJB3

0.03

0.0001

connexon channel activity

M12529

APOE

0.21

0.0001

metabolism

NM_004925

AQP3

0.01

0.0003

transporter activity

  1. Partial list of differentially expressed genes identified in leiomyomas (African Americans and Caucasians) as compared to keloid/incisional scars as shown in Fig. 1. The genes were selected based on p ranking of p ≤ 0.005 and 2-fold cutoff change selection (F. Change) as described in materials and methods. Table 2 displays the under-expressed genes in leiomyomas as compared to keloid/incisional scars.