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Table 1 Effects of miglustat administration on the fertility of male mice and rabbits as assessed by natural mating.

From: The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study

Species

Strain

Pregnancies/male

Pups/litter

  

Control

Miglustat

Control

Miglustat

Rabbit

Russen-Kaninchen

1.0 ± 0.0

1.0 ± 0.0

7.0 ± 1.2

7.2 ± 1.5

Mouse

C57BL/6

2.6 ± 0.9

0.0 ± 0.0*

6.7 ± 1.0

N/A

 

129S1/SvImJ

1.6 ± 0.5

1.6 ± 0.5

8.2 ± 0.6

8.9 ± 1.9

 

FVB/N

2.6 ± 1.5

2.2 ± 1.5

6.7 ± 1.6

6.0 ± 0.7

 

DBA/2

3.0 ± 0.7

2.8 ± 1.1

7.5 ± 0.8

6.3 ± 1.3

 

AKR/J

1.8 ± 0.4

1.4 ± 0.5

6.2 ± 2.3

3.6 ± 1.5

 

MA/MyJ

1.6 ± 0.5

0.8 ± 0.8

7.8 ± 0.8

3.8 ± 3.3

  1. Data were obtained from 5 males/5 × 1 female (rabbits), from 5 males/5 × 4 females per strain (C57BL/6, FVB/N and DBA/2), or from 5 males/5 × 2 females per strain (129S1/SvImJ, AKR/J and MA/MyJ). Miglustat administration to rabbits and mice was at 50 and 150 mg/kg/day, respectively. Data are expressed as means ± SD. Only the value marked with (*) is statistically different from control (P < 0.0002).
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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