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Table 1 Effects of miglustat administration on the fertility of male mice and rabbits as assessed by natural mating.

From: The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study

Species Strain Pregnancies/male Pups/litter
   Control Miglustat Control Miglustat
Rabbit Russen-Kaninchen 1.0 ± 0.0 1.0 ± 0.0 7.0 ± 1.2 7.2 ± 1.5
Mouse C57BL/6 2.6 ± 0.9 0.0 ± 0.0* 6.7 ± 1.0 N/A
  129S1/SvImJ 1.6 ± 0.5 1.6 ± 0.5 8.2 ± 0.6 8.9 ± 1.9
  FVB/N 2.6 ± 1.5 2.2 ± 1.5 6.7 ± 1.6 6.0 ± 0.7
  DBA/2 3.0 ± 0.7 2.8 ± 1.1 7.5 ± 0.8 6.3 ± 1.3
  AKR/J 1.8 ± 0.4 1.4 ± 0.5 6.2 ± 2.3 3.6 ± 1.5
  MA/MyJ 1.6 ± 0.5 0.8 ± 0.8 7.8 ± 0.8 3.8 ± 3.3
  1. Data were obtained from 5 males/5 × 1 female (rabbits), from 5 males/5 × 4 females per strain (C57BL/6, FVB/N and DBA/2), or from 5 males/5 × 2 females per strain (129S1/SvImJ, AKR/J and MA/MyJ). Miglustat administration to rabbits and mice was at 50 and 150 mg/kg/day, respectively. Data are expressed as means ± SD. Only the value marked with (*) is statistically different from control (P < 0.0002).