Figure 2

Venn diagram showing the number of genes induced by E2 and EDs. The altered gene profiles by E2, OP and DES (overlapped 21 genes; A) or NP, BPA and Gen (overlapped 30 genes B), respectively, were summarized. A hierarchical clustering analysis (C) was performed following treatments with E2 and other EDs in the uterus of immature rats. Two-dimensional hierarchical clustering was applied to the expression data from 7.5 k genes, which showed significant changes in the balanced differential expression. Increased expression levels are shown in red and decreased expression levels are shown in green.