Figure 1
From: Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men
Four putative missense mutations in the DAZL protein. (a) Pictoral representation of the DAZL gene, with exons depicted by red arrows and the coding region depicted by an orange arrow. Two protein motifs, the RNA Recognition Motif (RRM) and the DAZ repeat, are represented by green and pink arrows, respectively. Each mutation is labeled by its exon and its position in the gene, which is mapped to the sequence as previously reported [28]. (b) Sequence of the DAZL protein, with mutated residues in bold, and the resulting changed amino acid above in red. The highly conserved RRM, which is required for RNA binding, is underlined (LPE........to IRK) [36, 42]. Another highly conserved domain of the protein, the DAZ motif, is underlined with double arrows (AYP....... to NYQ).