Regulation of ovulation rate in mammals: contribution of sheep genetic models

Table 1 Identified major genes affecting ovulation rate in sheep

Name	Gene (Chromosome)	allele	Mutation pro/mature protein	Founder breed	Reference
Inverdale	BMP-15 (X)	FecX ^I	V299D/V31D	Romney	[3]
Hanna		FecX ^H	Q291stop/Q23stop	Romney	[3]
Belclare		FecX ^B	S367I/S99I	Belclare	[9]
Galway		FecX ^G	T239stop/no	Belclare, Cambridge	[9]
Lacaune X-linked		FecX ^L	C321Y/C53Y	Lacaune	[13]
High Fertility	GDF-9 (5)	FecG ^H	S395F/S77F	Belclare, Cambridge	[9]
Booroola	BMPR-1B (6)	FecB ^B	Q249R	Merino, Garole, Javanese, Hu, Han	[21–25]

GenBank accession numbers: BMP-15 (AH009593); GDF-9 (AF078545); BMPR-1B (AF312016)

ISSN: 1477-7827