Table 1 Net inhibitory effect of thrombin, PAR-1 and PAR1-AP on human umbilical artery tone.
Thrombin (n = 6) | (% ± SEM) | PAR1-AP (n = 6) | (% ± SEM) | PAR-1 Antagonist (n = 6) | (% ± SEM) | (P Value) |
|---|---|---|---|---|---|---|
0.5 U/ml | #28.90 ± 2.60 | 10 -9 M | *23.91 ± 5.64 | 10 -9 M | 2.83 ± 3.05 (NS) | (0.630) |
1 U/ml | *35.39 ± 3.91 | 10 -8 M | *37.32 ± 2.29 | 10 -8 M | 3.80 ± 2.33 (NS) | (0.471) |
2 U/ml | *44.72 ± 2.31 | 10 -7 M | *52.39 ± 1.28 | 10 -7 M | 5.60 ± 3.74 (NS) | (0.228) |
3 U/ml | *53.51 ± 4.62 | 10 -6 M | *61.50 ± 1.43 | 10 -6 M | 7.03 ± 5.74 (NS) | (0.148) |
|  |  |  |  | 10 -5 M | 6.87 ± 4.48 (NS) | (0.815) |