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Table 1 Net inhibitory effect of thrombin, PAR-1 and PAR1-AP on human umbilical artery tone.

From: Effects of thrombin, PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro

Thrombin (n = 6) (% ± SEM) PAR1-AP (n = 6) (% ± SEM) PAR-1 Antagonist (n = 6) (% ± SEM) (P Value)
0.5 U/ml #28.90 ± 2.60 10 -9 M *23.91 ± 5.64 10 -9 M 2.83 ± 3.05 (NS) (0.630)
1 U/ml *35.39 ± 3.91 10 -8 M *37.32 ± 2.29 10 -8 M 3.80 ± 2.33 (NS) (0.471)
2 U/ml *44.72 ± 2.31 10 -7 M *52.39 ± 1.28 10 -7 M 5.60 ± 3.74 (NS) (0.228)
3 U/ml *53.51 ± 4.62 10 -6 M *61.50 ± 1.43 10 -6 M 7.03 ± 5.74 (NS) (0.148)
     10 -5 M 6.87 ± 4.48 (NS) (0.815)
  1. Values presented represent the mean inhibitory effects on umbilical artery tone i.e. after adjusting for control / vehicle experiments. The values provided represent % inhibition ± standard error of the mean (SEM). The PAR1-AP used was Threonine-Phenylalanine-Leucine-leucine-Arginine-NH2. The PAR-1 antagonist used was Ser- pFPhe-pGPe-Leu-Arg-Orn-NH2. The values were compared with amplitude measurements observed prior to drug addition (NS not significant, # P < 0.01, * P < 0.001).