Table 4 Genes with the highest connectivity scores among all (198) genes down-regulated in the testes of ABP-TG mice.

MAPK8

AB005663

1000

2.70

Signal transduction; protein kinase

IL-2

K02292

673

3.73

Cytokine; growth factor; extracellular

IL-4

AA967539

681

2.05

Cytokine; humoral defense; extracellular

IL-10

M37897

427

3.32

Cytokine; immune response; extracellular

HGF

X72307

392

2.76

Hepatocyte growth factor; trypsin activity; extracellular

CREB1

X67719

344

2.14

Transcription factor, linked to cAMP signaling

GAST

AV062425

267

2.30

Gastrin; extracellular

MMP2

M843224

179

2.25

Matrix metalloprotease; type IV collagenase; extracellular

CD44

U57611

166

2.41

Hyaluronan receptor; cell surface glycoprotein

F10

AF087644

133

2.96

Coagulation factor X; serine protease; extracellular

MPO

X15313

129

3.32

Myeloperoxidase; antibacterial defence; extracellular

GHRH

M31654

103

2.00

Growth hormone releasing hormone; extracellular

ITIH4

AF023919

91

2.46

Trypsin inhibitor; extracellular

SLC9A

U51112

79

2.46

Ion channel; Na+/H+ exchanger; transmembrane protein

GFAP

X02801

74

2.14

Intermediate filament/structural protein; intracellular

VWF

AI843063

63

2.30

Von Willebrand factor; cell attachment; extracellular

SMARCA-4

AA097203

45

2.25

Transcription factor; chromatin remodeling; nucleus

HCRT

AF019566

38

2.46

Precursor of hypocretin neuropeptides; extracellular

GATA2

AV377670

37

3.18

Transcription factor; development; nucleus

NTRK3

AF035400

34

2.76

Cell surface receptor, non-catalytic isoform