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Figure 2 | Reproductive Biology and Endocrinology

Figure 2

From: Peroxisome proliferator-activated receptors (PPARs) and ovarian function – implications for regulating steroidogenesis, differentiation, and tissue remodeling

Figure 2

Mechanism of action of PPARs. PPARs heterodimerize with RXRs both in the presence and absence of ligand. After ligand binding, PPARs undergo conformational change resulting in dissociation of corepressors, and the binding of coactivators. PPAR/RXR heterodimers bind to a DR1 sequence in the promoter region of target genes (see text for details).

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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