Table 2 Genes differentially expressed in the adhesion fibroblasts and known to have roles in cell-adhesion, -proliferation, -migration, -differentiation and -death.

gi:17986276

Collagen, type IV alpha 2

2.4

2.7

See Discussion

gi:4506760

S100 calcium-binding protein A10

2.3

2.7

See Discussion

gi:6679055

Nidogen 2

6.4

7.1

See Discussion

gi:14250074

Transmembrane 4 superfamily member 1

3.7

2.6

See Discussion

gi:4758081

Chondroitin sulfate proteoglycan 2

3.4

3.2

See Discussion

gi:187538

Metallothionein 1E

4.3

4.0

See Discussion

gi:4336324

Small membrane protein 1

2.4

2.6

Cell viability [54]

gi:17738299

Cyclin-dependent kinase inhibitor 2A

2.0

2.0

Cell proliferation [55]

gi:16359382

Nuclear receptor subfamily 4, group A

1.6

2.1

Antagonizes TNF-α induced apoptosis [56]

gi:40353726

Synaptopodin

2.9

2.4

Actin cytoskeleton dynamics [57]

gi:23398519

Vasodilator-stimulated phosphoprotein

1.5

2.1

Enhances actin based cell motility, Cytoskeltal dynamics [58]

gi:28329

α-Smooth muscle actin

3.0

3.2

Myofibroblast transformation [44]

gi:14574570

Bcl-2 related gene bfl-1

1.6

1.4

Anti apoptotic; inhibitor of p53 induced apoptosis

gi:796812

p53 tumor suppressor

1.5

1.6

Cell cycle arrest and apoptosis [52]

gi:184522

Insulin-like growth factor binding protein 3

3.2

2.3

See Discussion

gi:4504618

Insulin-like growth factor binding protein 7

2.3

2.0

Growth suppressing factor [59]

gi:28610153

Interleukin 8

3.2

2.6

Inhibits fibroblast migration, delays wound healing, reduces wound contraction [60]

gi:4504982

Lectin, galactoside-binding, soluble 3 [galectin)

3.0

3.0

Tumor-suppressive and pro apoptotic [61]

gi:12803916

Gap junction protein, beta 1, [Connexin 32)

1.8

2.2

Tumor suppressive and Proapoptotic [62]

gi:14589894

Cadherin 5, type 2, VE-cadherin [vascular]

2.3

1.7

Down regulation associates with tumor metastasis, Initiates endothelial-mesenchymal transdifferentiation [63]

gi: 16198356

Lactotransferrin

2.2

2.1

Inhibits growth of malignant tumors. Elevated by high level of estrogen [64]

gi:21619838

Lipocalin 2, Oncogene 24p3

3.3

2.5

Proapoptotic [65]

gi: 23273645

Calponin 1, basic, Smooth muscle cell

1.7

2.5

Inhibits smooth muscle cell contraction and Tumor Suppressive [66]

gi:40225461

RAP1A, member of RAS oncogene family

1.8

1.6

Inhibits cell proliferation [67]

gi:4507112

Synuclein-gamma

1.5

1.3

Expression reduced in carcinoma [68]