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Table 2 Genes differentially expressed in the adhesion fibroblasts and known to have roles in cell-adhesion, -proliferation, -migration, -differentiation and -death.

From: Expression pattern and regulation of genes differ between fibroblasts of adhesion and normal human peritoneum

Accession Number Definition Fold Change Functions
   P1 P2*  
Increased in Intensity
gi:17986276 Collagen, type IV alpha 2 2.4 2.7 See Discussion
gi:4506760 S100 calcium-binding protein A10 2.3 2.7 See Discussion
gi:6679055 Nidogen 2 6.4 7.1 See Discussion
gi:14250074 Transmembrane 4 superfamily member 1 3.7 2.6 See Discussion
gi:4758081 Chondroitin sulfate proteoglycan 2 3.4 3.2 See Discussion
gi:187538 Metallothionein 1E 4.3 4.0 See Discussion
gi:4336324 Small membrane protein 1 2.4 2.6 Cell viability [54]
gi:17738299 Cyclin-dependent kinase inhibitor 2A 2.0 2.0 Cell proliferation [55]
gi:16359382 Nuclear receptor subfamily 4, group A 1.6 2.1 Antagonizes TNF-α induced apoptosis [56]
gi:40353726 Synaptopodin 2.9 2.4 Actin cytoskeleton dynamics [57]
gi:23398519 Vasodilator-stimulated phosphoprotein 1.5 2.1 Enhances actin based cell motility, Cytoskeltal dynamics [58]
gi:28329 α-Smooth muscle actin 3.0 3.2 Myofibroblast transformation [44]
gi:14574570 Bcl-2 related gene bfl-1 1.6 1.4 Anti apoptotic; inhibitor of p53 induced apoptosis
gi:796812 p53 tumor suppressor 1.5 1.6 Cell cycle arrest and apoptosis [52]
Decreased in Intensity
gi:184522 Insulin-like growth factor binding protein 3 3.2 2.3 See Discussion
gi:4504618 Insulin-like growth factor binding protein 7 2.3 2.0 Growth suppressing factor [59]
gi:28610153 Interleukin 8 3.2 2.6 Inhibits fibroblast migration, delays wound healing, reduces wound contraction [60]
gi:4504982 Lectin, galactoside-binding, soluble 3 [galectin) 3.0 3.0 Tumor-suppressive and pro apoptotic [61]
gi:12803916 Gap junction protein, beta 1, [Connexin 32) 1.8 2.2 Tumor suppressive and Proapoptotic [62]
gi:14589894 Cadherin 5, type 2, VE-cadherin [vascular] 2.3 1.7 Down regulation associates with tumor metastasis, Initiates endothelial-mesenchymal transdifferentiation [63]
gi: 16198356 Lactotransferrin 2.2 2.1 Inhibits growth of malignant tumors. Elevated by high level of estrogen [64]
gi:21619838 Lipocalin 2, Oncogene 24p3 3.3 2.5 Proapoptotic [65]
gi: 23273645 Calponin 1, basic, Smooth muscle cell 1.7 2.5 Inhibits smooth muscle cell contraction and Tumor Suppressive [66]
gi:40225461 RAP1A, member of RAS oncogene family 1.8 1.6 Inhibits cell proliferation [67]
gi:4507112 Synuclein-gamma 1.5 1.3 Expression reduced in carcinoma [68]
  1. * Adhesion/Normal peritoneal fibroblasts values of gene expression intensity from patient 1 (P1) and 2 (P2).