Skip to main content

Table 1 Summary of the Effects of TNFα on Sertoli, Leydig, and Peritubular Cells

From: The role of tumor necrosis factor-alpha and interleukin-1 in the mammalian testis and their involvement in testicular torsion and autoimmune orchitis

Sertoli Cells

Leydig Cells

Peritubular Myoid Cells

increase cytochrome

decrease testosterone [52–56]

increase PAI-1 [57]

P450 aromatase [30]

  

increase NFκB activity [31]

  

increase AR [32]

  

decrease MIS [33]

  

increase transferrrin [37, 38]

  

increase LDH-A [39, 41]

  

decrease MCT2 [42]

  

decrease FasL [43]

  

increase Fas [44]

  

increase IGFBP-3 [45]

  

increase IL-6 [46, 47]

  

increase ICAM and VCAM [47]

  

increase MMP9 [48]

  

increase TIMP-1 and collagen [48]

  

decrease GST [49]

  
Back to article page

Reproductive Biology and Endocrinology

ISSN: 1477-7827

Contact us