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Table 1 Summary of the Effects of TNFα on Sertoli, Leydig, and Peritubular Cells

From: The role of tumor necrosis factor-alpha and interleukin-1 in the mammalian testis and their involvement in testicular torsion and autoimmune orchitis

Sertoli Cells Leydig Cells Peritubular Myoid Cells
increase cytochrome decrease testosterone [5256] increase PAI-1 [57]
P450 aromatase [30]   
increase NFκB activity [31]   
increase AR [32]   
decrease MIS [33]   
increase transferrrin [37, 38]   
increase LDH-A [39, 41]   
decrease MCT2 [42]   
decrease FasL [43]   
increase Fas [44]   
increase IGFBP-3 [45]   
increase IL-6 [46, 47]   
increase ICAM and VCAM [47]   
increase MMP9 [48]   
increase TIMP-1 and collagen [48]   
decrease GST [49]