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Table 1 Comparison of allele frequency of C677T MTHFR between cases, study controls, and population controls.

From: The C677T methylenetetrahydrofolate reductase variant and third trimester obstetrical complications in women with unexplained elevations of maternal serum alpha-fetoprotein

Subjects C/C (%) C/T (%) T/T (%) Comparing to study controls* OR (95%CI) Comparing to population* OR (95%CI)
Cases N = 54 21 (39) 27 (50) 6 (11) 1.73 (1.25–2.37) (p = 0.033) 1.70 (1.11–2.60) (p = 0.007)
Study Controls N = 73 40 (55) 30 (41) 3 (4) ~ 0.98 (0.46–1.55) (p = 0.410)
Population N = 977 557 (57) 352 (36) 68 (7) 0.98 (0.46–1.55) (p = 0.410) ~
  1. * χ2 comparison of allele frequency (total T and C) in each group, one tailed. Cases: women with unexplained elevations of MSAFP who had subsequent complications of pregnancy, (C = 69, T = 39) Controls: women who had unexplained elevations of MSAFP and no subsequent complications (C = 110, T = 36) Population controls were 977 newborns (C = 1466, T = 488) [12]. C/C = normal type, C/T = heterozygous for thermolabile variant, T/T = homozygous for thermolabile variant.