Overriding follicle selection in controlled ovarian stimulation protocols: Quality vs quantity

Table 1 Antihuman gonadotropin antibodies in macaque serum prior to and following three consecutive controlled ovarian stimulation (COS) cycles with recombinant human gonadotropins [46].

Protocol	Number of animals	¹²⁵I-hCG bound^a Before^b	¹²⁵I-hCG bound^a After^b	Number of animals	¹²⁵I-FSH bound^a Before^b	¹²⁵I-FSH bound^a After^b
First	12	3.1^c	2.9	12	2.6	2.6
Second^d	9	3.4	2.9	9	2.6	2.8
	2	3.8	7.0	2	3.0	6.6
Third^d	3	3.4	3.3	4	2.6	2.7
	6	3.1	7.0	4	2.8	6.5
	1	18.1	25.5	2	7.2	12.1

^aRepresents protein A precipitation of antibody-bound ¹²⁵I-hCG or ¹²⁵I-FSH in serum. Nonspecific binding was 2.5% and 2.3%, respectively. See [45] for methodologic details. ^b"Before" and "After" represents serum samples collected seven days prior to the first injection of COS cycle and the last two days of the luteal phase of the COS cycle, respectively. ^cBaseline levels of antibody were defined as ≤ 4% of bound radioactivity (negative response), borderline responses were represented by 4–9% of bound radioactivity, and positive responses were present if values ≥ 10%. ^dOne animal was ovariectomized prior to the second protocol; one animal did not exhibit an ovarian response to COS during the third protocol.

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