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Table 2 LOAELs and Efficacies for Pyrazine Derivatives in the Oviductal Assays

From: Pyrazine derivatives in cigarette smoke inhibit hamster oviductal functioning

LOAELs (M)a

 

Efficacies (%)b,c

Ciliary Beat Frequency

Oocyte Pickup Rate

Contraction Rate

Chemical

Ciliary Beat Frequency

Oocyte Pickup Rate

Contraction Rate

10-12

10-11

10-9

pyrazine

25

29

40

10-12

10-11

10-11

2-methylpyrazine

11*

43*

61**

10-12

10-11

10-12

2-ethylpyrazine

3**

45*

38

10-8

10-11

10-9

2,5-dimethylpyrazine

34

10*

40

10-6

10-9

10-7

2,6-dimethylpyrazine

5**

3**

85***

10-9

10-10

10-9

2,3,5-trimethylpyrazine

18

10*

58**

10-9

10-12

10-12

2-methoxy-3-methylpyrazine

18

13*

17**

  1. aLOAEL is lowest observable adverse effect level bEfficacy is the mean percentage of inhibition at the LOAEL cStudent's t-Test was performed on efficacies comparing each chemical back to pyrazine for each bioassay. * p < 0.05; ** p < 0.01; *** p < 0.001.
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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