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Table 2 LOAELs and Efficacies for Pyrazine Derivatives in the Oviductal Assays

From: Pyrazine derivatives in cigarette smoke inhibit hamster oviductal functioning

LOAELs (M)a   Efficacies (%)b,c
Ciliary Beat Frequency Oocyte Pickup Rate Contraction Rate Chemical Ciliary Beat Frequency Oocyte Pickup Rate Contraction Rate
10-12 10-11 10-9 pyrazine 25 29 40
10-12 10-11 10-11 2-methylpyrazine 11* 43* 61**
10-12 10-11 10-12 2-ethylpyrazine 3** 45* 38
10-8 10-11 10-9 2,5-dimethylpyrazine 34 10* 40
10-6 10-9 10-7 2,6-dimethylpyrazine 5** 3** 85***
10-9 10-10 10-9 2,3,5-trimethylpyrazine 18 10* 58**
10-9 10-12 10-12 2-methoxy-3-methylpyrazine 18 13* 17**
  1. aLOAEL is lowest observable adverse effect level bEfficacy is the mean percentage of inhibition at the LOAEL cStudent's t-Test was performed on efficacies comparing each chemical back to pyrazine for each bioassay. * p < 0.05; ** p < 0.01; *** p < 0.001.