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Table 5 The EC 50 and maximal transcriptional activity of the traditional Chinese medicine (TCM) and its 18 components that were determined in the HELN-ERα and HELN-ERβ cell lines

From: Evidence of ERalpha and ERbeta selectivity and partial estrogen agonism in traditional Chinese medicine

  ERα ERβ
Max. luciferase activity % EC50% Max. luciferase activity % EC50%
Traditional Chinese medicine   107.4 0.035 78 0.015
Huang Jing A 48   51  
Huang Qi B 80 0.2 100 0.055
Gu Sai Bu C 34   23  
Ru Xiang D 38   23  
Lu Rong E 74   33  
Ji Nei Jin F 94 0.2 86.5 0.03
Bai Ji Li G 44   33  
Mai Men Dong H 93   38  
Mo Yao I 43 0.009 37 0.004
Shu Di J 78 0.04 61 0.02
Shan yao K 73   45  
Shan Zu Yu L 69 0.3 49 0.4
Chai Hu M 57 0.1 43 0.1
Ze Xie N 33   20  
Shen Qu O 100   61  
Gan Cao P 111 0.004 92 0.002
Fu Ling Q 108   45  
Chen Pi R 85 0.07 35 0.035
  1. The EC50 values of the herbal medicine and the 18 components are expressed as percentages and correspond to dilutions of the TCM or component (1% = 100-fold dilution). The percentage of maximum luciferase activity (100%) was determined when the cells were exposed to 10-8M E2. The complete identification code of the 18 herbal components is explained in Table 2.