Evidence of ERalpha and ERbeta selectivity and partial estrogen agonism in traditional Chinese medicine

Table 4 Maximal transcriptional activity of 17β estradiol (E ₂ ); the phyotoestogen, genistein; the sesquiterpenoid, ferutinin; the traditional Chinese medicine (TCM); and the six selected components of the herbal medicine that were determined in the HELN-ERα, HELN-ERβ, HELN-ΔA/BERα, and HELN-ΔA/BERβ cell lines

	ERα	ΔΑ/β ERα	ERα vs ΔΑ/β ERα	ERβ	ΔΑ/β ERβ	ERβ vs ΔΑ/β ERβ
	*Max luciferase activity (%)*		p-value	*Max luciferase activity (%)*		p-value
E ₂	100	100		100	100
Genistein	121	117		115.9	77.6
Ferutinin	99.1	87.9		38.8	12
Traditional Chinese medicine	107.4	58	0.014	78	56	<0.001
B	80	39.6	NS	100	50	0.021
F	94	57	0.002	86.5	53	<0.001
J	78	29	NS	61	35	NS
L	69	23	NS	49	16	NS
P	111	70	0.021	92	73	NS
R	85	33	0.004	35	19	NS

Significant p-values corresponding to Student’s t-test are reported (NS: not significant at the 5% significance level).

ISSN: 1477-7827