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Table 4 Maximal transcriptional activity of 17β estradiol (E 2 ); the phyotoestogen, genistein; the sesquiterpenoid, ferutinin; the traditional Chinese medicine (TCM); and the six selected components of the herbal medicine that were determined in the HELN-ERα, HELN-ERβ, HELN-ΔA/BERα, and HELN-ΔA/BERβ cell lines

From: Evidence of ERalpha and ERbeta selectivity and partial estrogen agonism in traditional Chinese medicine

  ERα ΔΑ/β ERα ERα vs ΔΑ/β ERα ERβ ΔΑ/β ERβ ERβ vs ΔΑ/β ERβ
  Max luciferase activity (%) p-value Max luciferase activity (%) p-value
E 2 100 100   100 100  
Genistein 121 117   115.9 77.6  
Ferutinin 99.1 87.9   38.8 12  
Traditional Chinese medicine 107.4 58 0.014 78 56 <0.001
B 80 39.6 NS 100 50 0.021
F 94 57 0.002 86.5 53 <0.001
J 78 29 NS 61 35 NS
L 69 23 NS 49 16 NS
P 111 70 0.021 92 73 NS
R 85 33 0.004 35 19 NS
  1. Significant p-values corresponding to Student’s t-test are reported (NS: not significant at the 5% significance level).