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Table 5 Genes previously described to be progesterone regulated that are down-regulated in endometrium of subjects with repeated embryo implantation failure

From: Endometrial gene expression reveals compromised progesterone signaling in women refractory to embryo implantation

UniGene ID Gene symbol Gene title Up regulated in window of implantation Down regulated in endometriosis or mifepristone Fold change p value
Hs.386793 GPX3 Glutathione peroxidase 3 (plasma) (GPX3), mRNA. [25, 27, 29, 32]   0.01 0.00013
Hs.458355 C1S Complement component 1, s subcomponent, transcript variant 1, mRNA. [28, 29]   0.02 0.00043
Hs.647023 CLDN3 Claudin 3 [24]   0.07 0.00086
Hs.89603 MUC1 Mucin 1, transmembrane, mRNA. [25] [4] 0.11 0.00022
Hs.436657 CLU Clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J), transcript variant 1, mRNA. [27, 29, 31, 32]   0.12 0.00086
Hs.276770 CD52 CD52 molecule   [7] 0.14 0.00043
Hs.498173 SMPD1 Sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase), transcript variant 1, mRNA. [24, 26]   0.14 0.00013
Hs.523414 LOC492304 Putative insulin-like growth factor II associated protein, mRNA. [27]   0.15 0.00022
Hs.532325 PAEP Progestagen-associated endometrial protein [24, 25, 27, 31, 32] [39] 0.15 0.00086
Hs.590970 AXL AXL receptor tyrosine kinase [24]   0.15 0.00022
Hs.163893 PICALM Phosphatidylinositol binding clathrin assembly protein   [4] 0.16 0.00086
Hs.525607 TNFAIP2 Tumor necrosis factor, alpha-induced protein 2, mRNA. [27–29, 32]   0.18 0.00043
Hs.654439 APOE Apolipoprotein E [24, 29]   0.18 0.00086
Hs.201978 PTGS1 Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), transcript variant 2, mRNA. [29] [7] 0.19 0.00013
Hs.82071 CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, mRNA. [25]   0.19 0.00086
Hs.524518 STAT6 Signal transducer and activator of transcription 6, interleukin-4 induced, mRNA. [29]   0.19 0.00022
Hs.478588 BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51), transcript variant 1, mRNA. [25, 27, 29]   0.20 0.00086
Hs.1012 C4BPA Complement component 4 binding protein, alpha [24, 25, 27, 29, 31, 32] [39] 0.22 0.00043
Hs.21765 FADS3 Fatty acid desaturase 3, mRNA. [26]   0.23 0.00043
Hs.4055 KLF6 Kruppel-like factor 6 [25]   0.23 0.00013
Hs.332708 FBLN5 Fibulin 5, mRNA. [27, 29]   0.23 0.00022
Hs.25292 JUNB Jun B proto-oncogene, mRNA. [25, 26]   0.25 0.00043
Hs.431048 ABL1 V-abl Abelson murine leukemia viral oncogene homolog 1, transcript variant b, mRNA. [24]   0.27 0.00086
Hs.190783 HAL Histidine ammonia-lyase [26, 32]   0.27 0.00086
Hs.513984 FLII Flightless I homolog (Drosophila), mRNA. [24, 32]   0.27 0.00043
Hs.643357 ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 [29]   0.29 0.00022
Hs.44227 HPSE Heparanase [29]   0.29 0.00086
Hs.515536 RRAS Related RAS viral (r-ras) oncogene homolog, mRNA. [27]   0.29 0.00013
Hs.409578 STK38 Serine/threonine kinase 38 [26]   0.29 0.00043
Hs.549171 C1orf56 Chromosome 1 open reading frame 56   [7] 0.29 0.00022
Hs.494457 NINJ1 Ninjurin 1, mRNA. [26]   0.29 0.00013
Hs.270291 ACTN4 Actinin, alpha 4 (ACTN4), mRNA. [29]   0.29 0.00086
Hs.381099 LCP1 Lymphocyte cytosolic protein 1 (L-plastin), mRNA. [28, 29]   0.31 0.00043
Hs.185172 GNB2 Guanine nucleotide binding protein (G protein), beta polypeptide 2, mRNA. [26]   0.31 0.00013
Hs.1497 RARG Retinoic acid receptor, gamma   [7] 0.33 0.00043
Hs.474751 MYH9 Myosin, heavy polypeptide 9, non-muscle, mRNA. [29]   0.33 0.00043
Hs.255093 PFKL Phosphofructokinase, liver, transcript variant 2, mRNA. [24]   0.33 0.00086
Hs.503911 NNMT Nicotinamide N-methyltransferase [25, 27]   0.33 0.00043
Hs.504877 ARHGDIB Rho GDP dissociation inhibitor (GDI) beta , mRNA. [24, 26, 27, 29]   0.33 0.00022
Hs.210995 CA12 Carbonic anhydrase XII, transcript variant 2, mRNA. [27, 32]   0.35 0.00043
Hs.520640 ACTB Actin, beta, mRNA.   [7] 0.35 0.00086
Hs.514819 AP2B1 Adaptor-related protein complex 2, beta 1 subunit, mRNA. [24]   0.35 0.00013
Hs.511605 ANXA2 Annexin A2, transcript variant 2, mRNA. [29]   0.35 0.00086
Hs.87752 MSN Moesin, mRNA. [29]   0.35 0.00022
Hs.654958 ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2   [7] 0.35 0.00013
Hs.443577 TNFRSF21 Tumor necrosis factor receptor superfamily, member 21 [29] [4] 0.35 0.00086
Hs.591868 ZBTB10 Zinc finger and BTB domain containing 10   [4] 0.35 0.00043
Hs.25348 VAMP2 Vesicle-associated membrane protein 2 (synaptobrevin 2)   [4] 0.38 0.00086
Hs.159161 ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha, mRNA. [24] [7] 0.38 0.00022
Hs.131269 RARRES1 Retinoic acid receptor responder (tazarotene induced) 1 [27]   0.38 0.00086
Hs.513915 CLDN7 Claudin 7, mRNA. [25]   0.38 0.00013
Hs.10326 COPE Coatomer protein complex, subunit epsilon, transcript variant 2, mRNA. [24]   0.38 0.00013
Hs.416024 NRSN2 Neurensin 2   [7] 0.38 0.00043
Hs.434248 PLEC Plectin [26, 29] [39] 0.38 0.00086
Hs.584854 AVIL Advillin [26, 29]   0.41 0.00022
Hs.183109 MAOA Monoamine oxidase A [24, 25, 27, 28, 31, 32]   0.41 0.00013
Hs.365405 SELO Selenoprotein O   [4] 0.41 0.00013
Hs.645228 KIR3DL1 Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 [29]   0.41 0.00086
Hs.528299 HTATIP HIV-1 Tat interacting protein, 60 kDa, transcript variant 3, mRNA. [26]   0.41 0.00043
Hs.164226 THBS1 Thrombospondin 1, mRNA. [29]   0.41 0.00086
Hs.647078 CDK5 Cyclin-dependent kinase 5   [7] 0.41 0.00043
Hs.278573 CD59 CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344), transcript variant 2, mRNA. [29]   0.41 0.00022
Hs.515162 CALR Calreticulin   [7] 0.41 0.00043
Hs.465744 INSR Insulin receptor [26]   0.41 0.00013
Hs.274256 ELOVL7 ELOVL family member 7, elongation of long chain fatty acids (yeast)   [4] 0.44 0.00086
Hs.450230 IGFBP3 Insulin-like growth factor binding protein 3 [27, 29, 32]   0.44 0.00086
Hs.504687 MYL9 Myosin, light polypeptide 9, regulatory [27]   0.44 0.00022
Hs.446641 ARAF V-raf murine sarcoma 3611 viral oncogene homolog, mRNA. [25]   0.44 0.00086
Hs.2030 THBD Thrombomodulin [25, 27, 29]   0.44 0.00013
Hs.104672 FILIP1L Filamin A interacting protein 1-like [27]   0.44 0.00086
Hs.75862 SMAD4 SMAD family member 4   [4] 0.44 0.00022
Hs.520757 TBXAS1 Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A), transcript variant TXS-II, mRNA. [29]   0.47 0.00013
Hs.283741 EXOSC5 Exosome component 5   [7] 0.47 0.00086
Hs.174312 TLR4 Toll-like receptor 4, transcript variant 2, mRNA. [29]   0.47 0.00043
Hs.24601 FBLN1 Fibulin 1 [31] [7] 0.47 0.00086
Hs.501728 RHOG Ras homolog gene family, member G (rho G)   [7] 0.47 0.00043
Hs.220864 CHD2 Chromodomain helicase DNA binding protein 2   [4] 0.47 0.00086
Hs.524809 CLIP1 CAP-GLY domain containing linker protein 1 [29]   0.47 0.00043
Hs.92236 MLL4 Myeloid/lymphoid or mixed-lineage leukemia 4   [7] 0.47 0.00086
Hs.654688 MKL1 Megakaryoblastic leukemia (translocation) 1 [26]   0.47 0.00043
Hs.279837 GSTM2 Glutathione S-transferase mu 2 (muscle) [26]   0.47 0.00086
Hs.645227 TGFB1 Transforming growth factor, beta 1   [7] 0.50 0.00086
Hs.149261 RUNX1 Runt-related transcription factor 1 [27]   0.50 0.00013
Hs.522818 L1CAM L1 cell adhesion molecule (hydrocephalus, stenosis of aqueduct of Sylvius 1, MASA (mental retardation, aphasia, shuffling gait and adducted thumbs) syndrome, spastic paraplegia 1) [26]   0.50 0.00043
Hs.840 IDO1 Indoleamine 2,3-dioxygenase 1 [24, 25, 29]   0.50 0.00086
Hs.2256 MMP7 Matrix metalloproteinase 7 (matrilysin, uterine) [27]   0.50 0.00043
  1. Data is expressed as fold change for endometrial genes down-regulated ≥2-fold in group A vs. group B that have been shown either up-regulated during the window of implantation or down-regulated in women with endometriosis or treated with mifepristone. Bolded transcripts are decreased also in group A vs. Group C.
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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