Table 5 Genes previously described to be progesterone regulated that are down-regulated in endometrium of subjects with repeated embryo implantation failure

Hs.386793

GPX3

Glutathione peroxidase 3 (plasma) (GPX3), mRNA.

[25, 27, 29, 32]

0.01

0.00013

Hs.458355

C1S

Complement component 1, s subcomponent, transcript variant 1, mRNA.

[28, 29]

0.02

0.00043

Hs.647023

CLDN3

Claudin 3

[24]

0.07

0.00086

Hs.89603

MUC1

Mucin 1, transmembrane, mRNA.

[25]

[4]

0.11

0.00022

Hs.436657

CLU

Clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J), transcript variant 1, mRNA.

[27, 29, 31, 32]

0.12

0.00086

Hs.276770

CD52

CD52 molecule

[7]

0.14

0.00043

Hs.498173

SMPD1

Sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase), transcript variant 1, mRNA.

[24, 26]

0.14

0.00013

Hs.523414

LOC492304

Putative insulin-like growth factor II associated protein, mRNA.

[27]

0.15

0.00022

Hs.532325

PAEP

Progestagen-associated endometrial protein

[24, 25, 27, 31, 32]

[39]

0.15

0.00086

Hs.590970

AXL

AXL receptor tyrosine kinase

[24]

0.15

0.00022

Hs.163893

PICALM

Phosphatidylinositol binding clathrin assembly protein

[4]

0.16

0.00086

Hs.525607

TNFAIP2

Tumor necrosis factor, alpha-induced protein 2, mRNA.

[27–29, 32]

0.18

0.00043

Hs.654439

APOE

Apolipoprotein E

[24, 29]

0.18

0.00086

Hs.201978

PTGS1

Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), transcript variant 2, mRNA.

[29]

[7]

0.19

0.00013

Hs.82071

CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, mRNA.

[25]

0.19

0.00086

Hs.524518

STAT6

Signal transducer and activator of transcription 6, interleukin-4 induced, mRNA.

[29]

0.19

0.00022

Hs.478588

BCL6

B-cell CLL/lymphoma 6 (zinc finger protein 51), transcript variant 1, mRNA.

[25, 27, 29]

0.20

0.00086

Hs.1012

C4BPA

Complement component 4 binding protein, alpha

[24, 25, 27, 29, 31, 32]

[39]

0.22

0.00043

Hs.21765

FADS3

Fatty acid desaturase 3, mRNA.

[26]

0.23

0.00043

Hs.4055

KLF6

Kruppel-like factor 6

[25]

0.23

0.00013

Hs.332708

FBLN5

Fibulin 5, mRNA.

[27, 29]

0.23

0.00022

Hs.25292

JUNB

Jun B proto-oncogene, mRNA.

[25, 26]

0.25

0.00043

Hs.431048

ABL1

V-abl Abelson murine leukemia viral oncogene homolog 1, transcript variant b, mRNA.

[24]

0.27

0.00086

Hs.190783

HAL

Histidine ammonia-lyase

[26, 32]

0.27

0.00086

Hs.513984

FLII

Flightless I homolog (Drosophila), mRNA.

[24, 32]

0.27

0.00043

Hs.643357

ADAMTS1

ADAM metallopeptidase with thrombospondin type 1 motif, 1

[29]

0.29

0.00022

Hs.44227

HPSE

Heparanase

[29]

0.29

0.00086

Hs.515536

RRAS

Related RAS viral (r-ras) oncogene homolog, mRNA.

[27]

0.29

0.00013

Hs.409578

STK38

Serine/threonine kinase 38

[26]

0.29

0.00043

Hs.549171

C1orf56

Chromosome 1 open reading frame 56

[7]

0.29

0.00022

Hs.494457

NINJ1

Ninjurin 1, mRNA.

[26]

0.29

0.00013

Hs.270291

ACTN4

Actinin, alpha 4 (ACTN4), mRNA.

[29]

0.29

0.00086

Hs.381099

LCP1

Lymphocyte cytosolic protein 1 (L-plastin), mRNA.

[28, 29]

0.31

0.00043

Hs.185172

GNB2

Guanine nucleotide binding protein (G protein), beta polypeptide 2, mRNA.

[26]

0.31

0.00013

Hs.1497

RARG

Retinoic acid receptor, gamma

[7]

0.33

0.00043

Hs.474751

MYH9

Myosin, heavy polypeptide 9, non-muscle, mRNA.

[29]

0.33

0.00043

Hs.255093

PFKL

Phosphofructokinase, liver, transcript variant 2, mRNA.

[24]

0.33

0.00086

Hs.503911

NNMT

Nicotinamide N-methyltransferase

[25, 27]

0.33

0.00043

Hs.504877

ARHGDIB

Rho GDP dissociation inhibitor (GDI) beta , mRNA.

[24, 26, 27, 29]

0.33

0.00022

Hs.210995

CA12

Carbonic anhydrase XII, transcript variant 2, mRNA.

[27, 32]

0.35

0.00043

Hs.520640

ACTB

Actin, beta, mRNA.

[7]

0.35

0.00086

Hs.514819

AP2B1

Adaptor-related protein complex 2, beta 1 subunit, mRNA.

[24]

0.35

0.00013

Hs.511605

ANXA2

Annexin A2, transcript variant 2, mRNA.

[29]

0.35

0.00086

Hs.87752

MSN

Moesin, mRNA.

[29]

0.35

0.00022

Hs.654958

ABCF2

ATP-binding cassette, sub-family F (GCN20), member 2

[7]

0.35

0.00013

Hs.443577

TNFRSF21

Tumor necrosis factor receptor superfamily, member 21

[29]

[4]

0.35

0.00086

Hs.591868

ZBTB10

Zinc finger and BTB domain containing 10

[4]

0.35

0.00043

Hs.25348

VAMP2

Vesicle-associated membrane protein 2 (synaptobrevin 2)

[4]

0.38

0.00086

Hs.159161

ARHGDIA

Rho GDP dissociation inhibitor (GDI) alpha, mRNA.

[24]

[7]

0.38

0.00022

Hs.131269

RARRES1

Retinoic acid receptor responder (tazarotene induced) 1

[27]

0.38

0.00086

Hs.513915

CLDN7

Claudin 7, mRNA.

[25]

0.38

0.00013

Hs.10326

COPE

Coatomer protein complex, subunit epsilon, transcript variant 2, mRNA.

[24]

0.38

0.00013

Hs.416024

NRSN2

Neurensin 2

[7]

0.38

0.00043

Hs.434248

PLEC

Plectin

[26, 29]

[39]

0.38

0.00086

Hs.584854

AVIL

Advillin

[26, 29]

0.41

0.00022

Hs.183109

MAOA

Monoamine oxidase A

[24, 25, 27, 28, 31, 32]

0.41

0.00013

Hs.365405

SELO

Selenoprotein O

[4]

0.41

0.00013

Hs.645228

KIR3DL1

Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1

[29]

0.41

0.00086

Hs.528299

HTATIP

HIV-1 Tat interacting protein, 60 kDa, transcript variant 3, mRNA.

[26]

0.41

0.00043

Hs.164226

THBS1

Thrombospondin 1, mRNA.

[29]

0.41

0.00086

Hs.647078

CDK5

Cyclin-dependent kinase 5

[7]

0.41

0.00043

Hs.278573

CD59

CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344), transcript variant 2, mRNA.

[29]

0.41

0.00022

Hs.515162

CALR

Calreticulin

[7]

0.41

0.00043

Hs.465744

INSR

Insulin receptor

[26]

0.41

0.00013

Hs.274256

ELOVL7

ELOVL family member 7, elongation of long chain fatty acids (yeast)

[4]

0.44

0.00086

Hs.450230

IGFBP3

Insulin-like growth factor binding protein 3

[27, 29, 32]

0.44

0.00086

Hs.504687

MYL9

Myosin, light polypeptide 9, regulatory

[27]

0.44

0.00022

Hs.446641

ARAF

V-raf murine sarcoma 3611 viral oncogene homolog, mRNA.

[25]

0.44

0.00086

Hs.2030

THBD

Thrombomodulin

[25, 27, 29]

0.44

0.00013

Hs.104672

FILIP1L

Filamin A interacting protein 1-like

[27]

0.44

0.00086

Hs.75862

SMAD4

SMAD family member 4

[4]

0.44

0.00022

Hs.520757

TBXAS1

Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A), transcript variant TXS-II, mRNA.

[29]

0.47

0.00013

Hs.283741

EXOSC5

Exosome component 5

[7]

0.47

0.00086

Hs.174312

TLR4

Toll-like receptor 4, transcript variant 2, mRNA.

[29]

0.47

0.00043

Hs.24601

FBLN1

Fibulin 1

[31]

[7]

0.47

0.00086

Hs.501728

RHOG

Ras homolog gene family, member G (rho G)

[7]

0.47

0.00043

Hs.220864

CHD2

Chromodomain helicase DNA binding protein 2

[4]

0.47

0.00086

Hs.524809

CLIP1

CAP-GLY domain containing linker protein 1

[29]

0.47

0.00043

Hs.92236

MLL4

Myeloid/lymphoid or mixed-lineage leukemia 4

[7]

0.47

0.00086

Hs.654688

MKL1

Megakaryoblastic leukemia (translocation) 1

[26]

0.47

0.00043

Hs.279837

GSTM2

Glutathione S-transferase mu 2 (muscle)

[26]

0.47

0.00086

Hs.645227

TGFB1

Transforming growth factor, beta 1

[7]

0.50

0.00086

Hs.149261

RUNX1

Runt-related transcription factor 1

[27]

0.50

0.00013

Hs.522818

L1CAM

L1 cell adhesion molecule (hydrocephalus, stenosis of aqueduct of Sylvius 1, MASA (mental retardation, aphasia, shuffling gait and adducted thumbs) syndrome, spastic paraplegia 1)

[26]

0.50

0.00043

Hs.840

IDO1

Indoleamine 2,3-dioxygenase 1

[24, 25, 29]

0.50

0.00086

Hs.2256

MMP7

Matrix metalloproteinase 7 (matrilysin, uterine)

[27]

0.50

0.00043