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Table 2 Effects of atorvastatin on blood concentrations of lipids and hormones

From: Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial

 

Control baseline

5-month treatment

3 months after withdrawal

Serum levels of lipids

Total cholesterol (g/L)

1.67 ± 0.08

1.27 ± 0.07***

1.71 ± 0.08

Triglycerides (g/L)

0.83 ± 0.06

0.73 ± 0.11

0.93 ± 0.14

HDL-C (g/L)

0.53 ± 0.03

0.52 ± 0.03

0.51 ± 0.03

LDL-C (g/L)

0.98 ± 0.07

0.57 ± 0.05***

0.98 ± 0.07

Serum levels of hormones

FSH (UI/L)

2.85 ± 0.30

2.87 ± 0.33

2.89 ± 0.30

LH (UI/L)

4.47 ± 0.54

5.00 ± 0.37

4.57 ± 0.35

Total testosterone (nmol/L)

22.71 ± 1.56

24.04 ± 1.99

22.81 ± 1.71

  1. Data are presented as mean ± SEM. Seventeen normocholesterolaemic men received 10 mg/d atorvastatin during 5 months as described in Methods. The serum levels of total cholesterol, triglycerides, HDL-C, LDL-C, FSH, LH and total testosterone were measured before, during and 3 months after the end of treatment. ***indicates values significantly different from those obtained before treatment with p < 0.001.