Figure 4
From: Molecular aspects of development and regulation of endometriosis
Intracellular regulation of TNF-alpha, VEGF-A, sICAM1 and annexin V. VEGF-A may activate annexin V, a marker of apoptosis, through VEGFR-2. TNF-alpha is regulated by such transcriptional factors as VDR, GATA-3, and NF-kB and is involved in signaling pathways of many growth factors. sICAM1, one of the adhesion molecules involved in the implantation and development of endometriotic lesions, is activated by NF-kB. There are a lot of drugs that have an effect on TNF-alpha, annexin V, VEGF-A and might be potentially used in the treatment of endometriosis.