Figure 5

Immunohistochemical localization of prostaglandin E2 synthase (PGES), PGE2 receptors EP2 and EP4 (PTGER2 and PTGER4), prostaglandin transporter (PGT, SLCO2A1) and of 15-prostaglandin dehydrogenase (HPGD). Immunohistochemical (IHC) localization of: (A-C) PGES, and (D-F) EP2 (PTGER2) in interplacental uterine sites during mid-gestation and during Aglepristone® (Agl.)-induced abortion. (G) Representative picture of EP4 (PTGER4) expression in interplacental site during Aglepristone® (Agl.)-induced abortion in mid-gestation dog. (H,I) Expression of PGT (SLCO2A1) in interplacental uterine site during mid-gestation and during Aglepristone® (Agl.)-induced abortion. (J-L) Uterine expression of HPGD in interplacental uterine sites during mid-gestation and after Aglepristone® (Agl.) treatment. Open arrows = surface (luminal) uterine epithelium, solid arrowheads = uterine glands, open arrowheads in (C), (F), (K), (L) = myometrium.