Recombinant human follicle-stimulating hormone (r-hFSH) plus recombinant luteinizing hormone versus r-hFSH alone for ovarian stimulation during assisted reproductive technology: systematic review and meta-analysis

Lehert, Philippe; Kolibianakis, Efstratios M; Venetis, Christos A; Schertz, Joan; Saunders, Helen; Arriagada, Pablo; Copt, Samuel; Tarlatzis, Basil

doi:10.1186/1477-7827-12-17

Table 1 Main characteristics of the studies included in the meta-analysis (n = 40)

From: Recombinant human follicle-stimulating hormone (r-hFSH) plus recombinant luteinizing hormone versus r-hFSH alone for ovarian stimulation during assisted reproductive technology: systematic review and meta-analysis

Study	Total number of patients in study	Patient response category^a	Age category (age restrictions)^b	GnRH agonist, GnRH antagonist or both	Insemination technique	Starting dose		Stimulation day (r-hLH initiated)
						r-hFSH (IU)	r-hLH (IU)
Williams 2000 [47]	60	Normal	None	Agonist	IVF/ICSI	300	25
MS8839 [48]	76	Normal	None	Agonist	IVF	150	75	1
MS9032 [49]	45	Normal	None	Agonist	ICSI	^c	75	1
MS9029 [50]	42	Poor	None	Agonist	ICSI	450	75	1
Balasch 2001 [51]	30	Normal	None	Agonist	IVF/ICSI	450	75	1
MS9640 [52]	141	Normal	None	Agonist	IVF/ICSI	225	75	1
Lisi 2002a [53]	453	Poor	None	Agonist	IVF	225	75	7
Lisi 2002b [54]	22	Normal	None	Agonist	IVF/ICSI	150	75	7
De Moustier 2002 [55]	169	Normal	Advanced	Agonist	IVF	225	^c
Ludwig 2003 [56]	20	Normal	None	Antagonist	IVF/ICSI		75
Sauer 2004 [57]	42	Normal	None	Antagonist	ICSI	225	150	7
Cedrin-Durnerin 2004 [58]	203	Normal	None	Antagonist	IVF/ICSI	^c	75
Ferraretti 2004 [10]	108	Poor	None	Agonist	IVF/ICSI	^c	^c
Humaidan 2004 [23]	231	Normal	Two subgroups	Agonist	IVF/ICSI	^c	^c	8
Marrs 2004 [25]	431	Normal	Two subgroups	Agonist	ICSI	225	150	6
Motta 2005 [27]	102	Poor	None	Both	IVF/ICSI		75
Griesinger 2005 [59]	127	Normal	None	Antagonist	IVF/ICSI	150	75	1
Demirol 2005 [60]	106	Poor	None	Antagonist	ICSI	450	150	1
De Placido 2005 [61]	130	Poor	None	Agonist	IVF/ICSI	225	150	8
Tarlatzis 2006 [62]	114	Normal	None	Agonist	IVF/ICSI	150	75
Ramirez 2006 [63]	34	Poor	None	Antagonist	IVF/ICSI	^c	150
Levi-Setti 2006 [64]	40	Normal	None	Antagonist	ICSI	225	75
Abdelmassih 2006 [65]	206	Normal	None	Agonist	IVF/ICSI	225	75	7
Aytac 2006 [66]	35	Poor	None	Agonist	ICSI		150
Fabregues 2006 [67]	120	Normal	Advanced	Agonist	IVF/ICSI	^c	150	6
Ruvolo 2007 [68]	42	Poor	None	Agonist	IVF/ICSI	225	^c	8
Polidoropoulos 2007 [69]	136	Poor	None	Agonist	ICSI	450	75
Berkkanoglu 2007 [70]	97	Normal	None	Agonist	ICSI	600	75	7
Nyboe Andersen 2008 [24]	526	Normal	Two subgroups	Agonist	IVF/ICSI	^c	^c	7
Barrenetxea 2008 [71]	84	Poor	Advanced	Agonist	ICSI	375	150	6
Pezzuto 2010 [72]	80	Normal	None	Agonist	ICSI	^c	75	6
Brunet 2009 [73]	94	Poor	None	Agonist	IVF		75	8
Gutman 2009 [74]	20	Normal	None	Agonist	IVF/ICSI	^c	75
Matorras 2009 [75]	131	Normal	Advanced	Agonist	ICSI	^c	150	6
Lahoud 2010 [76]	103	Normal	None	Agonist	IVF/ICSI		75	7
Kovacs 2010 [77]	50	Normal	None	Agonist	IVF/ICSI	150	75	1
Wiser 2011 [78]	30	Normal	None	Antagonist	IVF/ICSI	^c	75
Musters 2012 [79]	244	Poor	Advanced	Agonist	IVF/ICSI	^c	^c	1
Caserta 2011 [80]	999	Normal	None	Agonist	ICSI	150	75	7
Bosch 2011 [26]	720	Normal	Two subgroups	Antagonist	IVF/ICSI	^c	75	6
Total	6443

^aNormal = normal ovarian response, poor = poor/risk of poor ovarian response.
^bAdvanced = advanced maternal age, two subgroups = study had two age-based subgroups.
^cStarting dose varied according to numerous factors, such as patient age or body mass index; blank spaces indicate that the data were not reported by the study author.
GnRH, gonadotrophin-releasing hormone; ICSI, intracytoplasmic sperm injection; IVF, in vitro fertilization; r-hFSH, recombinant human follicle-stimulating hormone; r-hLH, recombinant human luteinizing hormone.
Note: the study by Musters et al. was included in the analysis prior to its publication in 2012.

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