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Table 1 Main characteristics of the studies included in the meta-analysis (n = 40)

From: Recombinant human follicle-stimulating hormone (r-hFSH) plus recombinant luteinizing hormone versus r-hFSH alone for ovarian stimulation during assisted reproductive technology: systematic review and meta-analysis

Study Total number of patients in study Patient response categorya Age category (age restrictions)b GnRH agonist, GnRH antagonist or both Insemination technique Starting dose Stimulation day (r-hLH initiated)
       r-hFSH (IU) r-hLH (IU)  
Williams 2000 [47] 60 Normal None Agonist IVF/ICSI 300 25  
MS8839 [48] 76 Normal None Agonist IVF 150 75 1
MS9032 [49] 45 Normal None Agonist ICSI c 75 1
MS9029 [50] 42 Poor None Agonist ICSI 450 75 1
Balasch 2001 [51] 30 Normal None Agonist IVF/ICSI 450 75 1
MS9640 [52] 141 Normal None Agonist IVF/ICSI 225 75 1
Lisi 2002a [53] 453 Poor None Agonist IVF 225 75 7
Lisi 2002b [54] 22 Normal None Agonist IVF/ICSI 150 75 7
De Moustier 2002 [55] 169 Normal Advanced Agonist IVF 225 c  
Ludwig 2003 [56] 20 Normal None Antagonist IVF/ICSI   75  
Sauer 2004 [57] 42 Normal None Antagonist ICSI 225 150 7
Cedrin-Durnerin 2004 [58] 203 Normal None Antagonist IVF/ICSI c 75  
Ferraretti 2004 [10] 108 Poor None Agonist IVF/ICSI c c  
Humaidan 2004 [23] 231 Normal Two subgroups Agonist IVF/ICSI c c 8
Marrs 2004 [25] 431 Normal Two subgroups Agonist ICSI 225 150 6
Motta 2005 [27] 102 Poor None Both IVF/ICSI   75  
Griesinger 2005 [59] 127 Normal None Antagonist IVF/ICSI 150 75 1
Demirol 2005 [60] 106 Poor None Antagonist ICSI 450 150 1
De Placido 2005 [61] 130 Poor None Agonist IVF/ICSI 225 150 8
Tarlatzis 2006 [62] 114 Normal None Agonist IVF/ICSI 150 75  
Ramirez 2006 [63] 34 Poor None Antagonist IVF/ICSI c 150  
Levi-Setti 2006 [64] 40 Normal None Antagonist ICSI 225 75  
Abdelmassih 2006 [65] 206 Normal None Agonist IVF/ICSI 225 75 7
Aytac 2006 [66] 35 Poor None Agonist ICSI   150  
Fabregues 2006 [67] 120 Normal Advanced Agonist IVF/ICSI c 150 6
Ruvolo 2007 [68] 42 Poor None Agonist IVF/ICSI 225 c 8
Polidoropoulos 2007 [69] 136 Poor None Agonist ICSI 450 75  
Berkkanoglu 2007 [70] 97 Normal None Agonist ICSI 600 75 7
Nyboe Andersen 2008 [24] 526 Normal Two subgroups Agonist IVF/ICSI c c 7
Barrenetxea 2008 [71] 84 Poor Advanced Agonist ICSI 375 150 6
Pezzuto 2010 [72] 80 Normal None Agonist ICSI c 75 6
Brunet 2009 [73] 94 Poor None Agonist IVF   75 8
Gutman 2009 [74] 20 Normal None Agonist IVF/ICSI c 75  
Matorras 2009 [75] 131 Normal Advanced Agonist ICSI c 150 6
Lahoud 2010 [76] 103 Normal None Agonist IVF/ICSI   75 7
Kovacs 2010 [77] 50 Normal None Agonist IVF/ICSI 150 75 1
Wiser 2011 [78] 30 Normal None Antagonist IVF/ICSI c 75  
Musters 2012 [79] 244 Poor Advanced Agonist IVF/ICSI c c 1
Caserta 2011 [80] 999 Normal None Agonist ICSI 150 75 7
Bosch 2011 [26] 720 Normal Two subgroups Antagonist IVF/ICSI c 75 6
Total 6443        
  1. aNormal = normal ovarian response, poor = poor/risk of poor ovarian response.
  2. bAdvanced = advanced maternal age, two subgroups = study had two age-based subgroups.
  3. cStarting dose varied according to numerous factors, such as patient age or body mass index; blank spaces indicate that the data were not reported by the study author.
  4. GnRH, gonadotrophin-releasing hormone; ICSI, intracytoplasmic sperm injection; IVF, in vitro fertilization; r-hFSH, recombinant human follicle-stimulating hormone; r-hLH, recombinant human luteinizing hormone.
  5. Note: the study by Musters et al. was included in the analysis prior to its publication in 2012.