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Figure 2 | Reproductive Biology and Endocrinology

Figure 2

From: VEGF-D-induced draining lymphatic enlargement and tumor lymphangiogenesis promote lymph node metastasis in a xenograft model of ovarian carcinoma

Figure 2

VEGF-D promotes lymphangiogenesis. (A) Footpads bearing tumor xenografts are injected with Evan’s blue dye, which appears in the lymph nodes (LNs) and lymphatic vessels (LVs). No Evans blue is observed in the blood vessels (BVs) and other adjacent tissues. (B) In the drainage route from the inguinal to the axillary LN, mice bearing xenografts overexpressing VEGF-D show dilated LVs (right panel), while LVs in mice bearing SKOV3 (left panel) or SKOV3/pcDNA (mid panel) xenografts show no apparent dilation. (C) LVs are not apparent on the tumor surface in mice bearing SKOV3 (left panel) or SKOV3/pcDNA (mid panel) xenografts. LVs are apparent and enlarged and form new networks (arrows) on the surface of tumors overexpressing VEGF-D.

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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