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Table 1 Cytological, histological, and follow-up results, including the serum levels of ovarian cancer tumour markers and the ROMA index (%), for women with ovarian hyperstimulation syndrome

From: Assessment of cells in the ascitic fluid of women with ovarian hyperstimulation syndrome: the clinical implications for subsequent ovarian malignancy

Case no. Age (y) Douglas puncture OIT Ascites cytology* Control histology Remarks CA-125 (U/mL) HE4 (pM) ROMA (%)
1 28 05/2006 CC + hMG + hCG P IV 06/2006, neg.# Tumor-free 45.2 40.1 4.9
2 23 03/2007 FSH + hMG + hCG P IV 05/2007, neg.# Tumor-free 27.1 47.9 7.0
3 24 10/2007 CC + FSH P IV 12/2007, neg.# Tumor-free 505.8 38.2 5.0
4 23 10/2007 CC + hCG P IV 12/2007, neg.# Tumor-free 40.5 39.9 4.8
5 26 11/2007 CC + FSH + hCG P III 02/2008, neg.# Tumor-free§ 19.2 51.6 8.1
6 30 02/2008 hMG + hCG P III 04/2008, neg.# Tumor-free 9.8 45.6 5.2
7 26 11/2008 FSH + hCG P III 01/2009, neg.# Tumor-free 38.1 45.2 6.2
8 30 11/2009 GnRH-a + hMG + hCG P III 01/2010, neg.# Tumor-free 56.3 37.4 4.2
9 34 10/2012 GnRH-a + FSH + hCG P III-IV 12/2012, neg.# Tumor-free$ 210.3 40.1 5.3
  1. The dates of the Douglas puncture and control histology tests are shown.
  2. OIT Ovarian induction therapy, CC Clomiphene citrate, hMG Human menopausal gonadotropin, hCG Human chorionic gonadotropin, GnRH-a Gonadotropin-releasing hormone analogue, FSH Follicle-stimulating hormone.
  3. *See Methods for a description of the cytologic stages P I-P V.
  4. #Negative histology, normal ovarian tissue.
  5. §Trigeminal pregnancy.
  6. $Missed abortion.
  7. The reference value for CA-125 is 0–39 U/ml and for HE4 is 0–150 pM.