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Table 1 Cytological, histological, and follow-up results, including the serum levels of ovarian cancer tumour markers and the ROMA index (%), for women with ovarian hyperstimulation syndrome

From: Assessment of cells in the ascitic fluid of women with ovarian hyperstimulation syndrome: the clinical implications for subsequent ovarian malignancy

Case no.

Age (y)

Douglas puncture

OIT

Ascites cytology*

Control histology

Remarks

CA-125 (U/mL)

HE4 (pM)

ROMA (%)

1

28

05/2006

CC + hMG + hCG

P IV

06/2006, neg.#

Tumor-free

45.2

40.1

4.9

2

23

03/2007

FSH + hMG + hCG

P IV

05/2007, neg.#

Tumor-free

27.1

47.9

7.0

3

24

10/2007

CC + FSH

P IV

12/2007, neg.#

Tumor-free

505.8

38.2

5.0

4

23

10/2007

CC + hCG

P IV

12/2007, neg.#

Tumor-free

40.5

39.9

4.8

5

26

11/2007

CC + FSH + hCG

P III

02/2008, neg.#

Tumor-free§

19.2

51.6

8.1

6

30

02/2008

hMG + hCG

P III

04/2008, neg.#

Tumor-free

9.8

45.6

5.2

7

26

11/2008

FSH + hCG

P III

01/2009, neg.#

Tumor-free

38.1

45.2

6.2

8

30

11/2009

GnRH-a + hMG + hCG

P III

01/2010, neg.#

Tumor-free

56.3

37.4

4.2

9

34

10/2012

GnRH-a + FSH + hCG

P III-IV

12/2012, neg.#

Tumor-free$

210.3

40.1

5.3

  1. The dates of the Douglas puncture and control histology tests are shown.
  2. OIT Ovarian induction therapy, CC Clomiphene citrate, hMG Human menopausal gonadotropin, hCG Human chorionic gonadotropin, GnRH-a Gonadotropin-releasing hormone analogue, FSH Follicle-stimulating hormone.
  3. *See Methods for a description of the cytologic stages P I-P V.
  4. #Negative histology, normal ovarian tissue.
  5. §Trigeminal pregnancy.
  6. $Missed abortion.
  7. The reference value for CA-125 is 0–39 U/ml and for HE4 is 0–150 pM.