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Table 4 Ovarian response and clinical outcomes: received rFSH on day of hCG or did not (Analysis Set 1)

From: Corifollitropin alfa or rFSH treatment flexibility options for controlled ovarian stimulation: a post hocanalysis of the Engage trial

 

Corifollitropin alfa

rFSH

 

No

Yes

No

Yes

 

n = 247

n = 469

n = 255

n = 466

Duration of stimulation, days, mean (SD)

9.6 (1.3)

9.6 (1.5)

9.3 (1.3)

9.1 (1.2)

Follicles on day 8 ≥11 mm, mean (SD)

13.4 (6.0)

12.3 (6.5)

11.1 (5.1)

11.5 (6.0)

Serum E 2 on day 8, pmol/l, median (P5, P95)

3382

2697

3075

2938

(1039, 8441)

(793, 8147)

(1057, 9432)

(995, 7854)

Follicles on day of hCG ≥11 mm, mean (SD)

16.7 (6.5)

15.3 (6.7)

13.6 (5.7)

13.8 (6.1)

E 2 on day of hCG, pmol/l, median (P5, P95)

5468

4221

4514

4331

(1982, 12,038)

(1497, 11,120)

(1736, 10,349)

(1600, 9799)

No. of oocytes retrieved, mean (SD)

14.8 (8.1)

13.6 (7.8)

12.4 (6.2)

12.7 (6.7)

No. of embryos obtained on day 3, mean (SD)

8.5 (5.4)

8.1 (5.5)

7.3 (4.4)

7.5 (4.8)

No. of GQEs obtained on day 3, mean (SD)

4.7 (4.1)

4.5 (4.4)

4.4 (3.5)

4.4 (3.9)

No. of GQEs transferred, mean (SD)

1.2 (0.8)

1.3 (0.8)

1.3 (0.8)

1.3 (0.7)

Cycle cancellation rate, n (%)

22 (8.9)

36 (7.7)

12 (4.7)

24 (5.2)

  1. SD standard deviation, P5 5th percentile, P95 95th percentile, E 2  estradiol, GQEs good-quality embryos.