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Table 1 Ovarian response and clinical outcomes: start treatment on cycle day 2 or cycle day 3 (Analysis Set 1)

From: Corifollitropin alfa or rFSH treatment flexibility options for controlled ovarian stimulation: a post hocanalysis of the Engage trial

 

Corifollitropin alfa

rFSH

 

Day 2

Day 3

Day 2

Day 3

 

n = 343

n = 368

n = 353

n = 364

Duration of stimulation, days, mean (SD)

9.8 (1.4)

9.4 (1.5)

9.4 (1.2)

9.0 (1.3)

Follicles on day 8 ≥11 mm, mean (SD)

12.0 (6.1)

13.4 (6.4)

11.4 (5.7)

11.4 (5.8)

Serum E 2 on day 8, pmol/l, median (P5, P95)

2562

3285

2743

3274

(837, 7524)

(840, 8918)

(987, 7487)

(1068, 8184)

Follicles on day of hCG ≥11 mm, mean (SD)

15.6 (6.5)

16.1 (6.9)

14.1 (6.0)

13.3 (5.8)

E 2 on day of hCG, pmol/l, median (P5, P95)

4239

4899

4110

4808

(1512, 11,891)

(1762, 11,671)

(1501, 9762)

(1740, 10,129)

No. of oocytes retrieved, mean (SD)

14.1 (8.1)

14.0 (7.9)

12.8 (6.6)

12.4 (6.5)

No. of embryos obtained on day 3, mean (SD)

8.2 (5.6)

8.3 (5.4)

7.5 (4.8)

7.4 (4.6)

No. of GQEs obtained on day 3, mean (SD)

4.5 (4.2)

4.6 (4.4)

4.4 (3.8)

4.4 (3.8)

No. of GQEs transferred, mean (SD)

1.2 (0.8)

1.3 (0.8)

1.3 (0.8)

1.4 (0.8)

Cycle cancellation rate, n (%)

24 (7.0)

34 (9.2)

19 (5.4)

17 (4.7)

  1. SD standard deviation, P5 5th percentile, P95 95th percentile, E 2  estradiol, GQEs good-quality embryos.