Figure 3

Sequential sections of the myometrial artery in gestational day 40, which in Figure1A and B displays immunoreactivity for Ang-(1–7) and ACE2. These show a moderate signal for kallikrein (Kal), a faint and scanty one for bradykinin R2 (B2R), vascular endothelial growth factor (VEGF) and its type 2 receptor (KDR), and no endothelial nitric oxide synthase (eNOS), in vascular smooth muscle (VSM) characterized by α-smooth muscle actin. These vasodilators are present in endothelial cells characterized by von Willebrand factor (vWF). Absence of cytokeratin (CK) positive cells demonstrates no intraarterial extravillous trophoblasts. (x200).