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Table 3 The embryos quality and outcome of IVF-ET

From: Endometriosis fertility index score maybe more accurate for predicting the outcomes of in vitrofertilisation than r-AFS classification in women with endometriosis

Characteristic   EFI r-AFS
Total ≤5 score ≥6 score z (χ 2 ) P c I-II stage III-IV stage z (χ2) P d
No. of cycles 199 84 115    61 138   
No. of oocytes retrieveda 8.0(4.0–12.0) 6.0(3.0–10.8) 9.0(5.0–14.0) −3.071 0.002 9.0(5.0–15.0) 7.0(3.0–11.3) −2.454 0.014
No. of fertilization 5.0(3.0–9.0) 4.0(2.0–8.0) 6.0(4.0–10.0) −3.292 0.001 6.0(4.0–10.0) 5.0(2.8–8.0) −2.493 0.013
No. of fertilization 2PNa 4.0(2.0-7.0) 3.5(1.0-7.0) 5.0(3.0–8.0) −2.735 0.006 5.0(3.0–9.0) 4.0(2.0-7.0) −1.851 0.064
Rate of 2PN fertilizationb 1082/1834(59.0%) 414/676(61.2) 668/1158(57.7) 2.232 0.135 379/671(56.5) 703/1163(60.4) 2.764 0.096
Rate of polypronucleus zygote(%)b 154/1834(8.4%) 51/676(7.5) 103/1158(8.9) 1.012 0.314 70/671(10.4) 84/1163(7.2) 5.698 0.017
No. of cleavage from 2PN 4.0(2.0–7.0) 3.0(1.0-6.0) 5.0(3.0–7.0) −2.980 0.003 5.0(3.0–9.0) 4.0(2.0–6.0) −2.082 0.037
Cleavage rate from 2PN zygoteb 1045/1236(84.5) 391/465(84.1) 654/771 (84.8) 0.121 0.728 372/449(82.9) 673/787(85.5) 0.696 0.404
Availability of embryos(%)b 924/1306(70.8) 347/496(70.0) 577/810(71.2) 0.242 0.623 310/475(65.3) 614/831(73.9) 10.862 0.001
Top quality embryos(%)b 139/1045(13.3) 53/391(13.6) 86/654(13.1) 0.035 0.852 52/372(13.9) 87/673(12.9) 0.230 0.632
No. Of embryos transferred 2.0(2.0–2.0) 2.0(1.0–2.75) 2.0(2.0-2.0) −1.920 0.055 2.0(2.0–3.0) 2.0(2.0–2.0) −2.349 0.019
Implantation rate(%)b 120/386(31.1) 37/148(25.0) 83/238(34.9) 4.153 0.042 43/131(32.8) 77/255(30.2) 0.279 0.597
Clinical pregnancy rate(%)b 85/199(42.7) 24/84(28.6) 61/115(53.0) 11.881 0.001 31/61(50.8) 54/138(39.1) 2.362 0.124
Accumulation rate of pregnancyb 107/199(53.8) 33/84(39.2) 74/115(64.3) 12.266 0.000 37/61(60.7) 70/138(50.7) 1.678 0.195
  1. Note: Rate of 2PN fertilisation = number of 2PN zygotes/number of oocytes retrieved; rate of polypronucleus zygotes = number of polypronucleus zygotes/number of oocytes retrieved; rate of cleavage from 2PN = number of cleavages from 2PN/number of zygotes; embryo availability rate = (number of frozen embryos + number of ET embryos)/number of cleavage-stage embryos; top-quality embryos = number of top-quality embryos/number of cleavage-stage embryos from 2PN; implantation rate = number of gestational sacs/number of ET embryos; clinical pregnancy rate = number of pregnancy cycles/number of embryo transfer cycles; accumulation rate of pregnancy = number of pregnancy cycles for fresh transferred embryos or freeze-thawed transferred embryos in a single cycle of ovulation stimulation/number of cycles for ovulation stimulation.
  2. Definition of top-quality embryo: seven to eight blastomeres of equal size and less than 10% fragmentation can be seen on day 3 ( Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology, 2011) [19].
  3. aThe non-normally distributed data are presented as median (25th-75th percentile). The non-parametric Mann–Whitney test was performed to calculate the Z-score.
  4. bThe chi-squared test was performed to compare rates between groups.
  5. cComparison between the EFI score ≤5 and ≥6 groups. (score ≤5 vs score ≥6).
  6. dComparison between the r-AFS stage I-II and stage III-IV groups (stage I-II vs stage III-IV).