Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial

Table 2 Presence of ovarian OSC and emergence of oogenesis in culture

Case #¹	Age²	POF	Diagnosis	CK+ OSC/ epithelial crypts		Oogenesis in primary and secondary cultures		Morulae
		pre/post menopause		left ov	right ov	primary	secondary
1	30	POF	POF	yes	yes	yes	N.A.	no
2	36	pre	PFD⁴	no	yes	yes	yes	no
3	38	POF	POF	no	no	no	N.A.	no
4	39	pre	endometriosis	yes	yes	yes	N.A.	no
5	40	POF	POF	yes	yes	yes	N.A.	no
6	42	pre	fibroids	yes	no	yes	yes	yes
7	43A	pre	menorrhagia	yes	yes	yes	yes	no
8	43B	pre	fibroids	yes	no	yes	yes	no
9	45	pre	endometriosis	yes	yes	yes	yes	yes
10	48A	pre	menorrhagia	no	yes	yes	yes	yes
11	48A	pre	fibroids	no	yes	yes	yes	no
12	49 ³	pre	PFD	no	no	no	N.A.	no
13	50 ³	pre	fibroids	no	no	no	N.A.	no
14	52 ³	post	ovarian cyst	no	no	no	N.A.	no
15	53	post	PFD	no	yes	yes	yes	no
16	55	post	uterine bleeding	yes	no	yes	yes	yes
17	60	post	PFD	no	yes	yes	yes	yes
18	67A	post	PFD	yes	yes	yes	N.A.	no
19	67B	post	PFD	yes	no	yes	N.A.	no

Evaluation of menopausal status, OSC in ovaries, and presence of oogenesis and morulae in primary and secondary ovarian cultures. Data adapted from [178] and [94] with permission, © Informa UK Ltd.
¹ Age arrangement.
² Letters are added in patients exhibiting identical age.
³ Perimenopausal women.
⁴ Pelvic floor disorders (uterine/vaginal prolapse with or without urinary incontinence).
POF, premature ovarian failure; pre, premenopause; post, postmenopause; N.A., not available.

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