Table 3 Patient genetic profiles: interpretation of physiology and biomarker levels

Low AMH levels; low AFC

Suggests that even high doses of FSH would be ineffective and that LH would not improve results

Patient would benefit from counselling to better understand her limited chances of success

FSH receptor variant (eg. Ser⁶⁸⁰); good AMH levels; good AFC

Suggests a good prognosis, but it also predicts a genetic hyposensitivity to FSH that should be considered when formulating COS treatment

v-LH (variant in β subunit of LH receptor)

Suggest that a patient might benefit from LH supplementation during COS