Table 1 Effect of progesterone, MPA, and NOMAC on the uterine weight in estradiol-benzoate-treated mice
Estradiol benzoate | Progestogen | Dose | No. of mice | Uterine weight |
|---|---|---|---|---|
(mg/mouse/3 days) | ||||
Subcutaneous administration a | ||||
– | – | – | 20 | 21.61 ± 1.37** |
0.1 | – | – | 10 | 32.88 ± 2.26 |
0.1 | Progesterone | 0.3 | 5 | 32.04 ± 1.38 |
0.1 | 0.6 | 5 | 30.46 ± 1.53 | |
0.1 | 0.9 | 5 | 29.78 ± 2.99 | |
0.1 | MPA | 0.3 | 5 | 27.50 ± 1.08 |
0.1 | 0.6 | 5 | 24.92 ± 2.37* | |
0.1 | 0.9 | 5 | 29.34 ± 2.42 | |
0.1 | NOMAC | 0.3 | 5 | 27.16 ± 3.22 |
0.1 | 0.6 | 5 | 23.72 ± 1.08** | |
0.1 | 0.9 | 5 | 23.94 ± 1.16** | |
Oral administration a | ||||
– | – | – | 40 | 12.31 ± 0.49 |
0.1 | – | – | 31 | 40.99 ± 2.11 |
0.1 | MPA | 0.3 | 8 | 30.08 ± 3.92* |
0.1 | 0.6 | 7 | 22.39 ± 3.09** | |
0.1 | 0.9 | 8 | 24.70 ± 2.27** | |
0.1 | NOMAC | 0.1 | 9 | 46.74 ± 4.48 |
0.1 | 0.3 | 16 | 29.22 ± 1.89** | |
0.1 | 0.6 | 28 | 30.97 ± 2.47** | |
0.1 | 0.9 | 16 | 25.07 ± 2.28** | |
0.1 | 1.8 | 9 | 25.09 ± 4.37** | |