Archived Comments for:
PreImplantation Factor (PIF) promoting role in embryo implantation: increases endometrial Integrin-α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua
The obligate heterodimer for the integrin alpha2 is beta1. The integrin beta3 can to my knowledge only associate with alphaIIb or alphav. AlphaIIbbeta3 is a platelet receptor whereas alphavbeta3 is widely expressed and is most likely recognized by SSA6 in your FACS assays.
I suggest to recheck the use of alpha2beta3 in your manuscript or provide evidence for their direct association.
alpha2beta3
16 July 2012
Dear Sir/Madam,
The obligate heterodimer for the integrin alpha2 is beta1. The integrin beta3 can to my knowledge only associate with alphaIIb or alphav. AlphaIIbbeta3 is a platelet receptor whereas alphavbeta3 is widely expressed and is most likely recognized by SSA6 in your FACS assays.
I suggest to recheck the use of alpha2beta3 in your manuscript or provide evidence for their direct association.
With kind regards,
Norman Sachs
Competing interests
none