Expression of the G protein-coupled estrogen receptor (GPER) in endometriosis: a tissue microarray study

Table 3 Frequencies of the stromal expression levels of GPER (nuclear and cytoplasmic) and the classical sex hormone receptors in normal endometrium and endometriosis

Receptor	Expression level	Endometrium	Endometriosis	p-value
GPER nuc	High	23/30 (76.7%)	74/74 (100%)	<0.001
	Low	7/30 (23.3%)	0/74
ER-alpha	High	25/30 (83.3%)	68/70 (97.1%)	0.02
	Low	5/30 (16.7%)	2/70 (2.9%)
ER-beta	High	2/30 (6.7%)	35/71 (49.3%)	<0.001
	Low	28/30 (93.3%)	36/71 (50.7%)
PR	High	30/30 (100%)	70/72 (97.2%)	0.6
	Low	0/30	2/72 (2.8%)

GPER G protein-coupled estrogen receptor (nuc nuclear staining); ER estrogen receptor; PR progesterone receptor. No cytoplasmic GPER expression was detected in the stroma of endometrium and endometriosis. P-Values were calculated by an exact 2-sided Pearson chi-square test; p ≤ 0.05 was considered as statistically significant and is reported in bold type.

ISSN: 1477-7827