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Table 3 Inmunohistochemical detection of Munc18c, PKCζ, phospho-PKCζ and Syntaxin-4, in samples from NPE and PCOSE-IR

From: Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS)

 

EPITHELIAL COMPARTMENT (IOD)

STROMAL COMPARTMENT (IOD)

 

NPE

PCOSE-IR

NPE

PCOSE-IR

Munc18c

1996 ± 503.9

3347 ± 656.8

1497 ± 336.1

3380 ± 819‡

PKC ζ

8137 ± 2285

4652 ± 810.6‡

2646 ± 928.8*

2745 ± 665

Phospho-PKC ζ

4765 ± 2351

276,4 ± 34.5

3274 ± 1661

346,7 ± 35.5‡

Syntaxin-4

44882 ± 11522

29900 ± 6695‡

12753 ± 3576*

15818 ± 3189

  1. The samples were semiquantified by IOD. Values are expressed as mean ± SEM. NPE = Normal Proliferative Endometrium; PCOSE-IR = women with Polycystic Ovary Syndrome with Insulin Resistance.*p < 0.05; Epithelium Compartment vs Stromal Compartment;‡ p < 0.05; NPE v/s PCOSE-IR.
  2. Abbreviations: AR Androgen Receptor, SHBG Sex hormone-binding globulin; FAI Free Androgen Index; HOMA IR Homeostasis Model Assessment Insulin resistance