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Figure 1 | Reproductive Biology and Endocrinology

Figure 1

From: Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia

Figure 1

Western blotting analysis of Snail and e-cadherin expression in the total protein extracts from human placentas. A representative immunoblot is shown (Snail) from at least four separate runs of each sample (A), and graph (C) demonstrating densitometry analysis of Snail protein levels in normal term, preeclamptic, and preterm placentas (n = 36, 32, 30 respectively). For Snail, the ANOVA test revealed a significant difference among the three groups (p value = 0.0100). However, the Tukey HSD post-hoc test only indicated a statistically significant difference when comparing the normal term group and the preeclampsia group (p value = 0.0085). The difference between the preterm and the preeclamptic samples was not significant (p = 0.0941). Representative immunoblot (e-cadherin) from three separate gels (B), and graph showing densitometry analysis of e-cadherin levels in the three groups studied (D) (n = 27, 24 and 15 for normal term, preeclamptic, and preterm placentas respectively). For e-cadherin, the ANOVA test also revealed a significant difference among the three groups (p value = 0.0265). Again, the Tukey HSD post-hoc test only indicated a statistically significant difference when comparing the normal term group and the preeclampsia group (p value = 0.0397). The difference between the preterm and normal term group was not statistically significant (p = 0.1). * p < 0.05; ** p < 0.01

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