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Figure 5 | Reproductive Biology and Endocrinology

Figure 5

From: Quantitative ELISAs for serum soluble LHCGR and hCG-LHCGR complex: potential diagnostics in first trimester pregnancy screening for stillbirth, Down’s syndrome, preterm delivery and preeclampsia

Figure 5

Analysis of PAPP-A, free hCGbeta and hCGbeta-sLHCGR complex in trisomic and control pregnancy serum samples. The distribution of PAPP-A, free hCGbeta MoM and hCG-LHCGR values (pmol/mL) from a prospective study (PS, n = 363) and a retrospective study (RS, n = 150) were plotted. The Down’s pregnancies (T21, n = 13 for PS and n = 30 for RS) in each plot are shown as dark closed triangles whereas the controls are shown by closed grey triangles in each plot. The cut-off values for PAPP-A and free hCGbeta detecting Down’s pregnancies were ≤0.5 MoM and ≥2.0 MoM respectively, as described [21]. The hCG-sLHCGR has low and high cut-off values. These values for detecting Down’s pregnancies were set at ≤5 pmol/mL and ≥170 pmol/mL, respectively. All data were log-transformed and the regions within these cut-off values in each plot are highlighted by shaded boxes.

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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