Figure 4
Cells of the dorsal raphe nuclei in 25-day-old rat pup. Nissl staining. Magnification, X400; a – a prenatally saline-treated (control), b – a pCPA-treated rat pup, pCPA was injected at a dose of 400 mg/kg, 2 ml, intraperitoneally to the female rat on day 9 of pregnancy. Note the evident cell loss and morphological alterations of neurons, that have large round and very light nuclei with a thin rim of cytoplasm with little Nissl' substance in a prenatally pCPA-treated rat pup as compared with control.