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Table 1 Summary of Reproductive Female Phenotypes in Mutant Mice models.

From: Mutant mouse models and their contribution to our knowledge of corpus luteum development, function and regression

Mutant mice models with preovulatory/luteal development defects/anomalies
MUTANT REPRODUCTIVE PHENOTYPE REF
aCDK2 Infertile – Follicle arrest with granulosa luteinization; Gigantism with multi tissue hyperplasia and benign adenomas in the pituitary [16, 78]
bCDK4 Impaired postovulatory progesterone secretion and disruption of implantation [12, 47, 48]
cp27kip Ovulation defect; granulosa cells continue to proliferate after luteinization [46]
dPDE4D Infertile – Follicles with entrapped oocytes that undergo luteinization [17]
eNrip1 Infertile – Unruptured follicles; granulosa cells undergo luteinization [18]
fCon-37 Infertile – Mature oocytes fail to ovulate [19]
gPRLR Infertile – Fewer follicles, reduced ovulation, irregular cycles, reduced fertilization rates, defective preimplantation embryo development an lack the ability to initiate pseudopregnancy [54]
hPRKO Infertile – Inability to ovulate, uterine hyperplasia, limited mammary development and inability to exhibit sexual behavior [11, 22, 23]
iαERKO αERKO females are acyclic, infertile and display enlarged, hemorrhagic cystic follicles with a high incidence of ovarian tumors [9, 10, 30]
jβERKO βERKO females are sub fertile, have decreased ovulation rates, fewer litters, less pups and sparse corpora lutea [10, 30, 79]
kLHR Infertile – arrested follicular development at the early antral stage [3840, 80]
lLats – 1 Infertile-Growth retardation and lack of mammary development; Most follicles are primary and secondary; No evidence of corpora lutea formation [43]
mC/EBPβ Infertile – Fail to initiate or maintain a pregnancy [42]
neNOS Irregular estrous cycle and reduced ovulation rate [20, 21]
Mutant mice models with reduced luteal function
MUTANT REPRODUCTIVE PHENOTYPE REF
oHyt Infertile – Continuous diestrous [50]
pTIMP-1 Corpora lutea develop/sub-optimal progesterone [51]
Mutant mice models with delayed or disrupted luteal regression
MUTANT REPRODUCTIVE PHENOTYPE REF
qFP No regression of corpora lutea and fail to spontaneusly undergo parturition [59, 60]
rCOX-1 Delayed parturition [57, 58]
sCOX-2 Reduced ovulation rates, reduced fertilization rates, implantation and decidualization defects [15]
tlpr Irregular follicular development/corpora lutea undergo luteolysis at irregular intervals [71]
ugld Irregular follicular development/corpora lutea undergo luteolysis at irregular intervals [71]
vTNFR Increased number of ovulations, irregular estrous cycles, eventually get locked into a diestrous phase [67]
wCasp3 Delayed structural luteal regression, independent of decrease in progesterone [76, 77]
xInsl3 Disrupted cycle length and increased ovarian apoptosis including follicles and corpora lutea [64]
  1. List of acronyms or abbreviations: aCyclin dependent kinase 2, bCyclin dependent kinase 4, cp27(kip), dType 4 cAMP-specific phosphodiesterase, eNuclear receptor co-repressor Nrip1 (a.k.a. RIP140), fConnexin-37, gProlactin receptor, hProgesterone receptor, iαEstrogen receptor, jβEstrogen receptor, kLuteinizing hormone receptor, lLarge tumor suppressor homolog 1, mCCAAT/enhancer-binding protein β, nEndothelial nitric oxide synthase, oHypothyroid, pTissue inhibitor of metalloproteinase-1, qProstaglandin F2α receptor, rCyclooxygenase-1, sCyclooxygenase-2, tlymphoproliferation, ugeneralized lymphoproliferative disease, vTumor necrosis factor receptor, wCaspase-3, xInsulin-like factor 3