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Table 1 Comparison of immunohistochemical staining for ERα, ERβ and AR in the testis, efferent ductules and initial segment of the epididymis of control and ICI 182,780 treated rats, as observed after 150 days of treatment.

From: The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules

  SC GC LC PC ED-P ED-D IS
ERα        
Con - - ++ -/+ +++ ++++ -
ICI - - - - - + -
ERβ        
Con +++ + + -/+ ++++ +++ ++++
ICI +++ + + -/+ ++++ +++ ++++
AR        
Con +++/+ - +++ +++ ++ +++ ++++
ICI +++/+ - +++ +++ ++ +++ ++++
  1. SC = Sertoli cells; GC = germ cells; LC = Leydig cells; PC = peritubular myoid cells; ED-P = proximal efferent ductules; ED-D = distal efferent ductules; IS = initial segment of the epididymis; Con = control; ICI = ICI 182,780 treated; - = negative; + = weak stain; ++ = moderate stain; +++ = strong stain; ++++ = strongest stain; -/+ = intermittent stain; +++/+ = variable intensity of stain depending on the seminiferous tubules stage.