Rete testis histology from control and ICI-treated groups on day 59 post treatment. A. Control rete testis filled in with black shading to show a very thin channel (RT) with seminiferous tubule on the left (ST). B. Higher magnification of control showing a nearly cuboidal epithelium with narrow lumen (double arrow). The side adjacent to the tunica albuginea (TA) was thinner than the side adjacent to the seminiferous tubules. C. ICI 182,780 treated rete testis (RT; filled with black shading) showing strong dilation (double arrow). Seminiferous tubules (ST) are normal. D. ICI treated rete epithelium that is decreased in height (arrow). Bar = 100 μm for A, C. Bar = 25 μm for B, D.