Letrozole-stimulated endometrial preparation protocol is a superior alternative to hormone replacement treatment for frozen embryo transfer in women with polycystic ovary syndrome, a cohort study

Table 2 Pregnancy and obstetric outcomes of HRT and LS groups

Outcomes	HRT cycles (n = 1700)	LS cycles (n = 2007)	P
Clinical pregnancy rate	1095(64.4)	1423(70.9)	< 0.001
Miscarriage rate	220(20.1)	209(14.7)	< 0.001
Early miscarriage rate	151(13.8)	148(10.4)	0.009
Hypertensive disorders of pregnancy	78(8.9)	81(6.7)	0.056
Gestational diabetes mellitus	181(20.7)	203(16.7)	0.020
Live birth rate	874(51.4)	1214(60.5)	< 0.001
Gestational age (weeks)	37.41 ± 2.34	37.43 ± 1.99	0.175
Preterm birth	278(31.8)	390(32.1)	0.878
Stillbirth	1(0.1)	0(0.00)	0.254
Mode of delivery			0.023
Vaginal	204(23.4)	337(27.8)
Cesarean delivery	668(76.6)	875(72.2)
Number of fetuses
1	701(80.2)	924(76.1)	0.048
2	173(19.8)	288(23.7)
3 or more	0(0)	2(0.2)
Birthweight
Singleton	3311.6 ± 540.13	3271.7 ± 507.03	0.039
Twin	2440.26 ± 520.42	2511.23 ± 434.49	0.199
SGA
Singleton	23(3.3)	55(6.0)	0.013
Twin	13(3.8)	22(3.8)	0.962
LGA
Singleton	140(20.0)	139(15.0)	0.009
Twin	53(15.3)	61(10.6)	0.035

Date were expressed as the mean ± standard deviation or number (%). Difference between the groups were analyzed by the Mann-Whitney U-test or chi-squared test

ISSN: 1477-7827