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  1. Review

    The myths surrounding mild stimulation in vitro fertilization (IVF)

    So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes...

    Raoul Orvieto, Valeria Stella Vanni and Norbert Gleicher

    Reproductive Biology and Endocrinology 2017 15:48

    Published on: 24 June 2017

  2. Research

    Oocyte polarized light microscopy, assay of specific follicular fluid metabolites, and gene expression in cumulus cells as different approaches to predict fertilization efficiency after ICSI

    The complex relationship between oocyte morphology, specific follicular fluid metabolites, gene expression in cumulus granulosa cells, and oocyte competence toward fertilization and embryo development still ne...

    Alberto Revelli, Stefano Canosa, Loredana Bergandi, Oleksii A. Skorokhod, Valentina Biasoni, Andrea Carosso, Angela Bertagna, Milena Maule, Elisabetta Aldieri, Maria Diletta D’Eufemia, Francesca Evangelista, Nicola Colacurci and Chiara Benedetto

    Reproductive Biology and Endocrinology 2017 15:47

    Published on: 23 June 2017

  3. Research

    The potential regulatory mechanisms of the gonadotropin-releasing hormone in gonadotropin transcriptions identified with bioinformatics analyses

    The regulation of gonadotropin synthesis and release by gonadotropin­releasing hormone (GnRH) plays an essential role in the neuroendocrine control of reproduction. However, the mechanisms underlying gonadotro...

    Wei Xiang, Baoyun Zhang, Fenglin Lv, Guangde Feng, Long Chen, Fang Yang, Ke Zhang, Chunyu Cao, Pingqing Wang and Mingxing Chu

    Reproductive Biology and Endocrinology 2017 15:46

    Published on: 17 June 2017

  4. Research

    Differences in utilization of Intracytoplasmic sperm injection (ICSI) within human services (HHS) regions and metropolitan megaregions in the U.S.

    Anecdotal evidence suggests that US practice patterns for ART differ by geographical region. The purpose of this study was to determine whether use of ICSI differs by region and to evaluate whether these rates...

    Pavel Zagadailov, Albert Hsu, David B. Seifer and Judy E. Stern

    Reproductive Biology and Endocrinology 2017 15:45

    Published on: 12 June 2017

  5. Research

    Effect of race and ethnicity on utilization and outcomes of assisted reproductive technology in the USA

    The purpose of this study was to determine the utilization and live birth rates of assisted reproductive technology (ART) modalities among various racial and ethnic groups in recent years.

    Alice J. Shapiro, Sarah K. Darmon, David H. Barad, David F. Albertini, Norbert Gleicher and Vitaly A. Kushnir

    Reproductive Biology and Endocrinology 2017 15:44

    Published on: 8 June 2017

  6. Research

    Activating transcription factor 3 promotes embryo attachment via up-regulation of leukemia inhibitory factor in vitro

    A receptive endometrium is essential for maternal-embryonic molecular communication during implantation. However, the specific molecular regulatory mechanisms of the endometrial capacity remain poorly understo...

    Xi Cheng, Jingyu Liu, Huizhi Shan, Lihua Sun, Chenyang Huang, Qiang Yan, Ruiwei Jiang, Lijun Ding, Yue Jiang, Jianjun Zhou, Guijun Yan and Haixiang Sun

    Reproductive Biology and Endocrinology 2017 15:42

    Published on: 2 June 2017

  7. Research

    Expression of genes associated with BMP signaling pathway in porcine oocytes before and after IVM – a microarray approach

    The full maturational capability of mammalian oocytes is accompanied by nuclear and cytoplasmic modifications, which are associated with proliferation and differentiation of surrounding cumulus cells. These ev...

    Joanna Budna, Marta Rybska, Sylwia Ciesiółka, Artur Bryja, Sylwia Borys, Wiesława Kranc, Katarzyna Wojtanowicz-Markiewicz, Michal Jeseta, Ewa Sumelka, Dorota Bukowska, Paweł Antosik, Klaus P. Brüssow, Małgorzata Bruska, Michał Nowicki, Maciej Zabel and Bartosz Kempisty

    Reproductive Biology and Endocrinology 2017 15:43

    Published on: 2 June 2017

  8. Research

    Natriuretic peptides improve the developmental competence of in vitro cultured porcine oocytes

    Natriuretic peptides (NPs), brain and C type NPs (BNP and CNP), were involved in the maintenance of porcine oocyte meiotic arrest. The present study investigated the effects of NPs on developmental competence ...

    Yanhao Zhang, Huarong Wang, Wei Liu, Ye Yang, Xiao Wang, Zhiyuan Zhang, Qirui Guo, Chao Wang and Guoliang Xia

    Reproductive Biology and Endocrinology 2017 15:41

    Published on: 30 May 2017

  9. Research

    p,p’-DDT induces testicular oxidative stress-induced apoptosis in adult rats

    The 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p’-DDT) is a known persistent organic pollutant and male reproductive toxicant. The present study is designed to test the hypothesis that oxidative stress m...

    Neila Marouani, Dorsaf Hallegue, Mohsen Sakly, Moncef Benkhalifa, Khémais Ben Rhouma and Olfa Tebourbi

    Reproductive Biology and Endocrinology 2017 15:40

    Published on: 26 May 2017

  10. Research

    Outcome of in vitro fertilization in women with subclinical hypothyroidism

    Previous studies examining associations between subclinical hypothyroidism (SCH) with in vitro fertilization (IVF) outcome indicate some benefits of levothyroxine (LT4) treatment. But IVF outcomes in treated S...

    YunYing Cai, LanPing Zhong, Jie Guan, RuiJin Guo, Ben Niu, YanPing Ma and Heng Su

    Reproductive Biology and Endocrinology 2017 15:39

    Published on: 25 May 2017

  11. Review

    Role of microRNAs in premature ovarian insufficiency

    Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follic...

    Ying Guo, Junyan Sun and Dongmei Lai

    Reproductive Biology and Endocrinology 2017 15:38

    Published on: 12 May 2017

  12. Research

    Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator

    The aim of this study was to compare pregnancy rates in patients undergoing IVF/ICSI with embryo transfer after 4 and 5 days of culture in a closed incubation system with integrated time-lapse imaging.

    Verena Holschbach, Julia Weigert, Jens Erik Dietrich, Sabine Roesner, Markus Montag, Thomas Strowitzki and Bettina Toth

    Reproductive Biology and Endocrinology 2017 15:37

    Published on: 8 May 2017

  13. Review

    Comparative neonatal outcomes in singleton births from blastocyst transfers or cleavage-stage embryo transfers: a systematic review and meta-analysis

    Comparative neonatal outcomes with respect to singleton births from blastocyst transfers or cleavage-state embryo transfers are controversial with respect to which method is superior. Many studies have yielded...

    Xingling Wang, Mingze Du, Yichun Guan, Bijun Wang, Junwei Zhang and Zihua Liu

    Reproductive Biology and Endocrinology 2017 15:36

    Published on: 4 May 2017

  14. Research

    Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats

    Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory ho...

    Xinghui Han, Yuanyuan He, Gulan Zeng, Yonghong Wang, Wen Sun, Junchao Liu, Yanyan Sun and Jian Yu

    Reproductive Biology and Endocrinology 2017 15:35

    Published on: 2 May 2017

  15. Research

    Association of skewed X-chromosome inactivation with FMR1 CGG repeat length and anti-Mullerian hormone levels: a cohort study

    Premutation range CGGn repeats of the FMR1 gene denote risk toward primary ovarian insufficiency (POI), also called premature ovarian failure (POF). This prospective cohort study was undertaken to determine if...

    David H. Barad, Sarah Darmon, Andrea Weghofer, Gary J. Latham, Filipovic-Sadic, Qi Wang, Vitaly A. Kushnir, David F. Albertini and Norbert Gleicher

    Reproductive Biology and Endocrinology 2017 15:34

    Published on: 28 April 2017

  16. Research

    A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use

    It has become increasingly apparent that the trophectoderm (TE) at blastocyst stage is much more mosaic than has been appreciated. Whether preimplantation genetic screening (PGS), utilizing a single TE biopsy ...

    Norbert Gleicher, Jacob Metzger, Gist Croft, Vitaly A. Kushnir, David F. Albertini and David H Barad

    Reproductive Biology and Endocrinology 2017 15:33

    Published on: 27 April 2017

  17. Research

    Effect of different artificial shrinkage methods, when applied before blastocyst vitrification, on perinatal outcomes

    In recent years, single blastocyst transfer combined with vitrification has been applied widely, which can maximize the cumulative pregnancy rate in per oocyte retrieval cycles and minimize the multiple pregna...

    Caizhu Wang, Guixue Feng, Bo Zhang, Hong Zhou, Jinhui Shu, Ruoyun Lin, Huanhua Chen and Zhulian Wu

    Reproductive Biology and Endocrinology 2017 15:32

    Published on: 26 April 2017

  18. Research

    Improving preimplantation genetic diagnosis (PGD) reliability by selection of sperm donor with the most informative haplotype

    The study is aimed to describe a novel strategy that increases the accuracy and reliability of PGD in patients using sperm donation by pre-selecting the donor whose haplotype does not overlap the carrier’s one.

    Mira Malcov, Veronica Gold, Sagit Peleg, Tsvia Frumkin, Foad Azem, Ami Amit, Dalit Ben-Yosef, Yuval Yaron, Adi Reches, Shimi Barda, Sandra E. Kleiman, Leah Yogev and Ron Hauser

    Reproductive Biology and Endocrinology 2017 15:31

    Published on: 26 April 2017

  19. Research

    Efficient vitrification of mouse embryos using the Kitasato Vitrification System as a novel vitrification device

    Currently, the cryopreservation of embryos and oocytes is essential for assisted reproductive technology (ART) laboratories worldwide. This study aimed to evaluate the efficacy of the Kitasato Vitrification Sy...

    Kenji Momozawa, Atsushi Matsuzawa, Yukio Tokunaga, Shiori Abe, Yumi Koyanagi, Miho Kurita, Marina Nakano and Takao Miyake

    Reproductive Biology and Endocrinology 2017 15:29

    Published on: 24 April 2017

  20. Research

    Immunolocalization of steroidogenic enzymes in the vaginal mucous of Galea spixii during the estrous cycle

    The synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthe...

    Amilton Cesar dos Santos, Alan James Conley, Moacir Franco de Oliveira, Gleidson Benevides Oliveira, Diego Carvalho Viana and Antônio Chaves de Assis Neto

    Reproductive Biology and Endocrinology 2017 15:30

    Published on: 24 April 2017

  21. Research

    Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model

    Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a bleeding disorder caused by maternal antibodies against paternal human platelet antigens (HPAs) on fetal platelets. Antibodies against HPA-1a are acc...

    Mariana Eksteen, Gøril Heide, Heidi Tiller, Yan Zhou, Nora Hersoug Nedberg, Inigo Martinez-Zubiaurre, Anne Husebekk, Bjørn R. Skogen, Tor B. Stuge and Mette Kjær

    Reproductive Biology and Endocrinology 2017 15:28

    Published on: 21 April 2017

  22. Research

    Mitochondrial content, oxidative, and nitrosative stress in human full-term placentas with gestational diabetes mellitus

    The purpose of this study was to determine the mitochondrial content, and the oxidative and nitrosative stress of the placenta in women with gestational diabetes mellitus (GDM).

    Joel Ramírez-Emiliano, Martha E. Fajardo-Araujo, Ismael Zúñiga-Trujillo, Victoriano Pérez-Vázquez, Cuauhtémoc Sandoval-Salazar and Jessica K. Órnelas-Vázquez

    Reproductive Biology and Endocrinology 2017 15:26

    Published on: 4 April 2017

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